Results 21 to 30 of about 6,365 (263)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The divine favour of the unworthy: When the fatherless son meets the Black Messiah
HTS Teologiese Studies/Theological Studies, 2011 This article engages with Andries van Aarde’s 2001 work on the historical Jesus, Fatherless in Galilee: Jesus as Child of God. It poses the question whether Van Aarde succeeds in overcoming the shortcomings of Western, Euro-centric, male dominated ...
Allan A. Boesak
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
The Pope’s Jesus book and the Christologies of the gospels
HTS Teologiese Studies/Theological Studies, 2011 This article maps out recent developments in the exegetical investigation of Jesus. It starts with a discussion of the Jesus book by Joseph Ratzinger/Benedict XVI, in which ‘canonical exegesis’ is used to argue that Johannine Christology is also present ...
Wim J.C. Weren
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
The continued importance of Jesus
HTS Teologiese Studies/Theological Studies, 1997 The different aspects of the influential nature of Jesus' life were handed down only after his death by those who met God on the basis of the traditions with regard to Jesus.
Andries van Aarde
doaj +1 more source
Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)
Arthritis Care &Research, Accepted Article.Objective VEXAS syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures. A VEXAS‐specific disease activity index (DAI) is an essential tool for reliably capturing changes in disease ...
Kevin Byram +25 more
wiley +1 more source
Die historiese Jesus, die Jesus-beweging en die vorming van die kerk
HTS Teologiese Studies/Theological Studies, 1995 The historical Jesus, the Jesus movement and the birth of the church. The article focuses on the birth of the church. The point at which the church began its existence is located within the boundaries of fonnative Judaism.
Andries van Aarde
doaj +1 more source