Results 161 to 170 of about 4,978,738 (338)
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Hydrological Summary for the UK: October 2010 [PDF]
, 2007 The monthly summary of hydrological conditions in the United Kingdom is compiled as part of the National Hydrological Monitoring Programme (a joint CEH and BGS enterprise).
Marsh, Terry, Sanderson, Felicity
core +6 more sources
Deep Mapping Uncertain Historical Sources
Journal for the History of KnowledgeThis article navigates through the challenge of preserving and presenting uncertainties in digital maps, which are used to reconstruct practical knowledge in early modern artists’ businesses. It introduces a novel methodology—deep mapping—as a multi-layered spatial visualization within the Geographical Information Systems (GIS).
openaire +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Fire Insurance Maps: Introduction and Glimpses into America's Glass Manufacturing History [PDF]
, 2013 Article introduces fire insurance maps as historical research tool in general but specifically for researchers interested in American glass manufacturing ...
Palmer, Kristi L.
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Marxism\u27s ‘Communicative Crisis’? Mapping Debates over Leninist Print-Media Practices in the 20th Century [PDF]
, 2006 Despite the scholarly neglect of Marxism’s ‘communicative crisis’, it was a topic of concern that was addressed, debated and negotiated over by party leaders, intellectuals and activists on a continuous basis throughout the 20th century.
Pimlott, Herbert
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Structural analyses of features in cultural landscapes based on historical cadastral maps and GIS [PDF]
, 2005 A landscape may appear to be ancient and to contain old man-made structures even if this is not the whole truth. Structures are moved, removed, replaced and added over the years. New users introduce new land use and management regimes.
Domaas, Stein Tage
core
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source