Results 181 to 190 of about 202,912,194 (286)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Drift-Aware Digital-Twin Readiness for Two-Stage Reverse Osmosis: Plant-Scale Time-Aware Machine Learning and Operating-Regime Validation. [PDF]

Membranes (Basel)
Es Sellami S, Taleb A, El Hachoumi M, Es Sellami A.   +3 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Using archaeometabolomics to characterise tobacco-usage in human cortical bone from 17th to 19th century Dutch communities. [PDF]

PLoS One
Bonicelli A, Davies-Barrett AM, Serrano Ruber M, Sandhu J, Jones DJL, Inskip SA.   +5 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Genomic Diversity and Population Structure of Tibetan Antelopes Sampled From the Selincuo Region. [PDF]

Ecol Evol
Gao S, Zhang Y, Yang Z, Song X, Kong W, Zhao Y, Ren Z.   +6 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

From Past to Present: Examining the Associations Between Historical Racialized Housing Interventions and Current-Day Neighborhood-level Outcomes: The Multi-Ethnic Study of Atherosclerosis. [PDF]

J Racial Ethn Health Disparities
Bonsu P, Hamilton DT, Hajat A, Hurvitz P, Mui Y, Wolfson JA, Pollack Porter KM, Crawford K, Adekoya H, Hirsch JA, Jones-Smith JC.   +10 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Selective multimodal representation and visitor appraisal in educational heritage: evidence from Chinese academies. [PDF]

Front Psychol
Niu W, Zeng Q, Liang F, Yu Y.
europepmc   +1 more source