Results 101 to 110 of about 1,389,572 (306)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Embracing the Culture of Resilience and Remembrance in Teaching Contested Historical Narratives

open access: yesDiscourse and Communication for Sustainable Education, 2018
The article focuses on a discourse of resilience and remembering and its interconnectedness in teaching contested historical narratives. History mainly consists of events, remembrance, narratives, rituals, discourses, and stereotypes which can facilitate
Franzenburg Geert   +2 more
doaj   +1 more source

Climate Change and Damage from Extreme Weather Events [PDF]

open access: yes
The risks of extreme weather events are typically being estimated, by federal agencies and others, with historical frequency data assumed to reflect future probabilities.
Robert Easton, Robert Repetto
core  

Faculty Seminar On Collaboration Syllabus [PDF]

open access: yes, 2016
This is a collectively-built, in-progress syllabus for a faculty seminar on the topic of collaboration at Swarthmore College, Spring 2016. Topics include competing definitions of collaboration across disciplines, formal and informal collaboration, rich ...
Buurma, Rachel Sagner   +1 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Interaction Order and Historical Body Shaping Children’s Making Projects—A Literature Review

open access: yesMultimodal Technologies and Interaction, 2019
The importance of familiarizing children with the Maker Movement, Makerspaces and Maker mindset has been acknowledged. In this literature review, we examine the complex social action of children, aged from 7 to 17 (K-12), engaging in technology Making ...
Behnaz Norouzi   +2 more
doaj   +1 more source

Connecting ICTs to development: The IDRC experience [PDF]

open access: yes, 2014
Book ReviewAlthough the editors speciªcally deny that this book is a historical account, it only narrowly escapes that label. The book does attempt to consolidate some 15 years of International Development Research Centre (IDRC)–sponsored action research
Abbott, P
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Global Symposium on Women in Fisheries [PDF]

open access: yes
All over the world, women contribute in multiple ways to the production, processing, marketing and management of fish and other living aquatic resources. The first ever Global Symposium on Women in Fisheries, held in Kaohsiung, Taiwan on 29 November 2001
Chao, N.H.   +8 more
core  

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

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