Results 151 to 160 of about 1,389,572 (306)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
ArdethThe text discusses time-related issues in architecture through a conversation with Liu Jiakun, one of China’s most prominent architects, who was recently awarded the Pritzker Prize.
Maurizio Meriggi
doaj
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Logan Historical Newspaper Transcription Project
, 2009 Presentation given to summer citizens' group in Logan, Utah to tell them about the Logan Historical Newspaper Transcription Project and recruit volunteer transcribers. This project entails manually correcting computer-generated transcriptions to improve discoverability of the full-text digitized versions of the predecessor to today's Herald Journal ...
Walters, Cheryl D., Smith, Phyllis
openaire +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Theological Mirrors: Crickets and the Chirping of Historical Projects
Radical Americas, 2017 doaj +2 more sources
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Disegnare conThe Historical Municipal Archive of Cadiz preserves a significant collection of documents that has been created by the Town Hall since 1596, the year in which the city was sacked by Anglo-Dutch troops and all previous documents were lost.
Gabriel Granado Castro +2 more
doaj
Evaluation of the contemporary cultural landscape based on multi-dimensional value coupling: Case study on the Grand Canal, Hangzhou section. [PDF]
PLoS OneDong W, Han W, Xu Y, Wang J.
europepmc +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source