Results 191 to 200 of about 1,401,279 (304)

Reframing bioinformatics capacity development in Africa: from training supply to research-driven demand. [PDF]

J Community Genet
Hussein J, Myovela H.
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Near future projections of tropical cyclone tracks over the Bay of Bengal using high resolution CMIP6 models. [PDF]

Sci Rep
Adsul R, Singh VK, Parekh A, Gnanaseelan C.   +3 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Data collected in a citizen scientist study uncover a new species record of Phoxinus minnow for Austria. [PDF]

Environ Monit Assess
Chai MJ, Bogutskaya NG, Reier S, Friedrich R, Rund H, Wanzenböck S, Wanzenböck J, Glaser F, Marcante S, Prowatke I, Jung M, Mikschi E, Palandačić A.   +12 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Institutional transformations for authentic community engaged and participatory research. [PDF]

J Clin Transl Sci
Wallerstein N, Eder MM, Carter-Edwards L, Castro-Reyes P, Gangarova T, Sprague Martinez L, Michener L.   +6 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

BugPrioritizeAI for multimodal test case prioritisation using bug reports, code changes, and test metadata. [PDF]

Sci Rep
Kalyani P, Rao CP, Goparaju B, Babu KK, Kandimalla PCR.   +4 more
europepmc   +1 more source