Results 201 to 210 of about 54,538,745 (285)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Reinforcement Learning-Based Temporal Knowledge Graph Reasoning for Predicting Chronic Gastritis Diagnosis and Treatment: Development and Validation Study. [PDF]

JMIR Med Inform
Qu X, Sun Z, Wang Y, Liu H, Yao L, Li D, Song G, Zhang R, Zhang X.   +8 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

New to cohort, not new to care: leveraging historical data in HIV clinical cohorts in the United States. [PDF]

Am J Epidemiol
Haw NJL, Hogan B, Humes E, Coburn SB, Zheng C, Cheng Y, Zhang Y, Gebo KA, Lam JO, Karris MY, Zalla LC, Horberg MA, Napravnik S, Gill MJ, Althoff KN, Lesko CR.   +15 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Bioclimatic conditions on the Labrador Peninsula coast in 1884-1889, with a comparison to 1991-2020 at Nain station. [PDF]

Int J Biometeorol
Chmist K, Araźny A, Przybylak R, Singh G, Wyszyński P.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Real-world outcomes with BCMA- and GPRC5D-targeting bispecific antibodies in plasma cell leukemia. [PDF]

Blood Adv
Gaballa MR, Julian K, Afrough A, Hansen DK, Goel U, De Menezes Silva Corraes A, Dima D, Rana M, Hosoya H, Mikkilineni L, Fogel L, Raza S, Banerjee R, Zanwar SS, Pasvolsky O, Sannareddy A, Borogovac A, Davis J, Green K, Biran N, Zolotov E, Herr M, Shune L, Ouchveridze E, DeJarnette S, Atrash S, Ferreri C, Richards T, Abid MB, Bal S, Ali HM, Ye JC, Richard S, Kaur G, Shain K, Castaneda-Puglianini O, Harada K, De Avila G, Rossi A, Hassan H, Anderson LD, Voorhees PM, Khouri J, Sidana S, Portuguese AJ, Janakiram M, Lee HC, Lin Y, Grajales-Cruz A, Patel KK, Sborov DW.   +50 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source