Results 111 to 120 of about 334,606 (308)

Enlivening the dying ruins: history and archaeology of the Jesuit Missions in Ethiopia, 1557–1632

open access: yesCulture & History Digital Journal, 2013
A summary is presented of the recent archaeological research led by the University Complutense of Madrid on the residences and monuments of the Jesuit missions in Ethiopia, most of them built at the end of the Mission period, between 1621 and 1632.
Víctor M. Fernández
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Primary Historical Sources in Archaeology: Methods

open access: yes, 2017
While there are a handful of defined methods for working with primary historical sources in archaeology, few archaeologists take these as their main points of departure or rely upon them too rigidly.
Rachel King
core   +1 more source

Scientific Heritage of Ravil Usmanovich Amirkhanov: Contribution to the Study of Tatar National Identity and Intercultural Interaction (Dedicated to the 80th Anniversary of his Birth)

open access: yesИз истории и культуры народов Среднего Поволжья
This article presents a comprehensive analysis of the scientific activities of Ravil Usmanovich Amirkhanov (1946–2006) – Doctor of Historical Sciences and Honored Scientist of the Republic of Tatarstan, whose works significantly influenced the study of ...
Airat Kh. Tukhvatulin
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Kansas State Historical Society News Releases, 2012

open access: yes, 2012
This internet resource contains news releases issued throughout the yearWood Stove Cooking Demonstrations,History Presentations, and Lunch at Grinter Place New Exhibit at Kansas Museum of History Includes Worlds Earliest Printed Map Kansas Day ...
Kansas State Historical Society
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Independent Verification of Historical Sources

open access: yes
This project develops a new methodological framework for historical research based on the principle of independent verification of sources. It explores the transformation of historiography in the digital age and challenges the limitations of ...
Igor Bogouchevski
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

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