Results 81 to 90 of about 18,883,264 (389)
Ruling the Commons. Introducing a new methodology for the analysis of historical commons
Despite significant progress in recent years, the evolution of commons over the long run remains an under-explored area within commons studies. During the last years an international team of historians have worked under the umbrella of the 'Common Rules '
Tine de Moor+4 more
doaj +1 more source
We developed an electronic treatment register for the DeWorm3 Project, a cluster-randomised, controlled trial in Benin, India, and Malawi testing the feasibility of interrupting transmission of soil-transmitted helminths through community-wide mass drug ...
William E. Oswald+19 more
doaj +1 more source
TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling+4 more
wiley +1 more source
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria+3 more
wiley +1 more source
Top Incomes in the Long Run of History
A recent literature has constructed top income shares time series over the long run for more than twenty countries using income tax statistics. Top incomes represent a small share of the population but a very significant share of total income and total ...
A. Atkinson, T. Piketty, Emmanuel Saez
semanticscholar +1 more source
Conceptual History, Cultural History, Social History
V. M. Zhivov’s introduction to Studies in Historical Semantics of the Russian Language in the Early Modern Period (2009), translated here for the first time, offers a critical survey of the historiography on Begriffsgeschichte, the German school of conceptual history associated with the work of Reinhart Koselleck, as well as of its application to the ...
openaire +5 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
Although dark matter is a central element of modern cosmology, the history of how it became accepted as part of the dominant paradigm is often ignored or condensed into an anecdotal account focused around the work of a few pioneering scientists.
G. Bertone, Dan Hooper
semanticscholar +1 more source
We read with interest the paper by Seitz et al. [(1)][1] focusing on mapping areas of spatiotemporal electrogram dispersion in patients with atrial fibrillation (AF). According to the authors, these areas represent “AF drivers” and their ablation is a personalized, more effective strategy ...
Gianni C+3 more
openaire +3 more sources
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson+7 more
wiley +1 more source