Results 51 to 60 of about 2,178,099 (312)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Newspaper “Rech” in the July Crisis of 1914
Vestnik MGIMO-Universiteta, 2014 This article examines the position of the newspaper "Rech" during the July crisis of 1914. "Rech", founded in 1906 by the Constitutional Democratic Party (Kadets), was on the eve of the First World War one of the most important liberal organs of the ...
B. S. Kotov
doaj +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
General relativity histories theory [PDF]
Brazilian Journal of Physics, 2005 9 pages, revtex, for the proceedings of the Piombino II ...
openaire +4 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Descolonizar a história: epistemologia disruptiva
Contemporânea, 2020 As estruturas discursivas que se encarregam da reconstituição da experiência antiga e contemporânea dos africanos e dos descendentes de africanos no mundo permanecem marcadas pelas convenções da escrita colonial.
Martial Ze Belinga
doaj +1 more source
Nigeria’s democracy: the trilemma of herdsmenism, terrorism and vampirism
Inkanyiso, 2017 Since the ‘invention’ of democracy by the Greek City States in the first half of the 5th Century B.C. and its popularisation after the American War of Independence in the 17th century, democracy has remained the most famous form of government.
Emmanuel O. Ojo
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
STIMULUS GENERALIZATION OF BEHAVIORAL HISTORY [PDF]
Journal of the Experimental Analysis of Behavior, 2003 Undergraduates responded under a variable‐ratio 30 schedule in the presence of a 25‐mm long line and on a differential‐reinforcement‐of‐low‐rate 6‐s schedule when a 13‐mm long line was present. Following this, a line‐length continuum generalization test was administered under a fixed‐interval 6‐s schedule (Experiment 1) or extinction (Experiment 2). In
openaire +2 more sources