Results 71 to 80 of about 2,178,099 (312)

“The struggle for universal peace” or “the deception policy”: The issue of international arbitration in American-German relations on the eve of the First World War. 1904–1914

open access: yesВестник Тамбовского университета. Серия: Гуманитарные науки
Importance. The problem of resolving military conflicts by peaceful means has attracted and continues to attract the attention of not only professional historians, but also broadest sectors of civil society.
V. K. Shatsillo
doaj   +1 more source

MUNZUR DAĞLARI ALT MİYOSEN ÇÖKELLERİ MOLLUSK TOPLULUĞU VE PALEOEKOLOJİSİ (DOĞU ANADOLU, TÜRKİYE)

open access: yesBulletin of the Mineral Research and Exploration, 2017
Araştırma konusu, Tunceli ili Ovacık ilçesinde yer alan Munzur Dağlarında yüzlek veren Miyosen yaşlı birimlerdir. Munzur Dağlarında Paleozoik’ten Senozoik’e kadar devam eden bir çökelim bulunmaktadır.
Müjde GÜRSOY
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

JOHN OF SALISBURY’S “SUMMA SCIENTIAE”: AUTHOR AND THE TEXTS IN CULTURE OF THE “RENAISSANCE OF THE TWELFTH CENTURY”

open access: yesВестник Мининского университета, 2017
The paper is dedicated on detail consideration of two types of John of Salisbury’s works (1115/1120-1180) - the big one including treatises “Entheticus de dogmate philosophorum”, “Policraticus”, “Metalogicon” and the small one, which involves two "Lifes"
A. K. Gladkov
doaj   +2 more sources

Mashhadis and Immigration: Redemptive Narratives and Practical Challenges

open access: yesReligions
This paper analyzes redemptive narratives constructed by Mashhadi Jewish immigrants through oral histories, memoirs, and life stories collected across generations. It examines how conceptions of religion, community, and family shaped their meaning-making
Hilda Nissimi
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Sexual health in general practice: history and the partner history [PDF]

open access: yesJournal of Family Planning and Reproductive Health Care, 2011
The 50th anniversary of the contraceptive pill has been much discussed, and women of the generation that obtained ‘the pill’ in its earliest days have been telling how they had to pretend they were married or had a fiance. A brief fictionalised account of this era was given in one of the earliest episodes of the nuanced television series, Mad Men ...
openaire   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

The Crusades from a Historical Perspective: Communication, Culture, and Religion

open access: yesReligions
The Crusades have attracted scholarly attention ever since Pope Urban II called for the recovery of the Holy Land at the Council of Clermont (27 December 1095) [...]
Sophia Menache
doaj   +1 more source

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