Results 31 to 40 of about 189,918 (307)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Italian Chemists’ Contributions to Named Reactions in Organic Synthesis: An Historical Perspective
Molecules, 2013 From the second half of the 19th century up to modern times, the tremendous contribution of Italian chemists to the development of science resulted in the discovery of a number of innovative chemical transformations.
Gianluca Papeo, Maurizio Pulici
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Humphry Davy e as cores dos antigos Humphry Davy and the colors of the ancients
Química Nova, 2008 This article examines ideas held by Humphry Davy (1778-1829) about permanence, progress, experiments and practical application regarding chemistry.
Maria Helena Roxo Beltran
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Образование и наука, 2019 Introduction. The didactic principle of education-in-studies is one of the most important instruments of quality education at all levels. Compliance with this principle enhances the results of methodological means educators choose.
U. K. Slabin
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Chemistry in Teaching
The Moral of the Phlogiston Theory [PDF]
Kemija u Industriji, 2015 The phlogiston theory, proposed in 1697 by German physician Georg Ernst Stahl (1659 – 1734), was the first scientific theory of combustion. However, it was abandoned by the end of the 18th century after the “Lavoisier revolution”, primarily because it ...
N. Raos
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
MICROSCALE CHEMISTRY IN LATIN AMERICA
Universitas Scientiarum, 2005 A brief account of the development of Microscale Chemistry in Latin America is here presented. The US National Microscale Chemistry Center (Merrimack College, Massachusetts) was instrumental in the initiationof several centers.
Jorge G. Ibáñez
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