Results 41 to 50 of about 189,918 (307)

Alguns aspectos históricos da classificação periódica dos elementos químicos Some historical aspects of the periodic classification of the chemical elements

Química Nova, 1997
A history of the periodic table of the elements is presented, from the first tentative classifications, passing through Meyer and Mendeleev, up to recent speculations on super-heavy elements still to be synthesized.
Mario Tolentino, Romeu C. Rocha-Filho, Aécio Pereira Chagas   +2 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Healing waters: Medicine, Chemistry, Relief and Extraordinary Cures in Britain in the Long Eighteenth Century

Etudes Epistémè
This article focuses on the use and theories of mineral waters to explore how healing can be understood as a multifaceted phenomenon by doctors and patients alike. In medical theory and practice around taking the waters, health improvements were expected
Sophie Vasset
doaj   +1 more source

Substitutos do " novo" mundo para as antigas plantas raras: um estudo de caso dos bálsamos " New" world substitutes for ancient rare plants: a study case on balsams

Química Nova, 2010
Convinced that the " true balsam" was lost forever, Conrad Gesner described other substances with similar healing virtues. However, he was not the only one in the 16th to search for other varieties of balsamic oleoresins.
Ana Maria Alfonso-Goldfarb, Márcia H. M. Ferraz, Maria Helena Roxo Beltran   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Johann Andreas Cramer e o "ensaio químico mineral" no século XVIII Johann Andreas Cramer and the "mineral chemical assaying" in the Eighteenth century

Química Nova, 2010
In this research, we seek to corroborate the contributions of Chemistry to the identification, extraction and classification of minerals in the XVIII century, as well as, to approach the discussion that History of Chemistry shouldn't be understood in ...
Andréa Bortolotto, Márcia Helena Mendes Ferraz   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Alchemy Chemistry: A Bit of Your Story / Alquimiando a química: um pouco de sua história

Diversitas Journal, 2016
This article is dedicated to lecture about a journal written by a degree in chemical Attico I. Chassot, since in our current education system is given emphasis to the great classics scientists like Ernest Rutherford, John Dalton, Niels Bohr and other ...
Ailson Darlan Sales Ferreira
doaj   +1 more source