Results 151 to 160 of about 4,206,396 (342)
History of Medical Education The First Graded Curriculum
, 1938 FRED C. ZAPFFE
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Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo +11 more
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Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
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Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
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Anselm of Aosta: The challenge of knowledge and education throughout intellect
Ricerche di Pedagogia e DidatticaIn this contribution, we aim to analyse the figure of Anselm of Aosta through a critical historical approach to bring to light how the concept of intellectus, which Anselm investigates, plays a key role from an educational point of view also. To this end,
Luca Odini
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ADDRESS OF THE PRESIDENT EARLY HISTORY OF MEDICAL EDUCATION IN CALIFORNIA
, 1928 Emmet Rixford
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Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
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Interview with Marianne Marcus [PDF]
, 2016 An oral history with Marianne Marcus, Professor Emerita at the University of Texas at Houston School of Nursing. Before she retired and assumed the title of Professor Emerita in 2104, Dr.
Marcus, Marianne, EdD, RN
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A History of Secondary Education in Pennsylvania
, 1934 C. B. Allen, James Mulhern
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Molecular Oncology, EarlyView.Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan +4 more
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