Results 181 to 190 of about 1,404,224 (304)

Prospective, randomised, placebo-controlled, phase 2 clinical trial assessing the efficacy and safety of oral vancomycin in patients with primary sclerosing cholangitis with/out inflammatory bowel disease in Italy: study protocol of VanC-IT trial. [PDF]

BMJ Open
Cristoferi L, D'Amato D, Maino C, Bernasconi D, Dinelli ME, Malandrin SMI, Facciotti F, Festa MM, Gerussi A, Rossi E, Malinverno F, Tettamanti P, Cazzaniga ME, Corso R, Ippolito D, Galimberti S, Invernizzi P, Carbone M.   +17 more
europepmc   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source

The Accuracy of Video-Assisted Thoracic Surgery Pleural Biopsy in Patients with Suspected Diffuse Pleural Mesothelioma: A Real-Life Study. [PDF]

J Clin Med
Balsamo L, Migliore E, Della Beffa E, Delsedime L, Lausi PO, Di Cuonzo D, Lococo F, Lyberis P, Mirabelli D, Papotti MG, Ruffini E, Guerrera F.   +11 more
europepmc   +1 more source

Quantifying Additive Manufacturing Vapor Plumes Using Laser‐Induced Breakdown Spectroscopy, Synchrotron X‐Ray Radiography and Simulations

Advanced Science, EarlyView.
This study presents a novel in situ laser‐induced breakdown spectroscopy system for monitoring metal vapors produced by the intense laser‐metal interactions in laser powder bed fusion additive manufacturing and laser welding. The insights from this new technique reveal changes in alloy compositions and provide the first in situ validation of multi ...
Anna C. M. Getley, Samy Hocine, Junji Shinjo, Chinnapat Panwisawas, Marta Majkut, Alexander Rack, Peter D. Lee, Michael Towrie, Chu Lun Alex Leung   +8 more
wiley   +1 more source

Cardiac Overload and Heart Failure Risk by NT-proBNP Levels in Older Adults with COPD Eligible for Single-Inhaler Triple Therapy: A Multicenter Longitudinal Study. [PDF]

J Clin Med
Sarzani R, Spannella F, Laureti G, Giordano P, Giulietti F, Gezzi A, Mari PV, Coppola A, Galeazzi R, Rosati Y, Kamberi E, Stronati A, Resedi A, Landolfo M.   +13 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Impact of Insulin Resistance and Preclinical Atherosclerosis Parameters in Long-Term Prediction of Cardiovascular Events: A Seven-Year Prospective Study. [PDF]

J Clin Med
Di Lisi D, Manno G, Madaudo C, Perone F, Leonforte F, Parlati ALM, Flex A, Novo S, Tondi P, Galassi AR, Novo G.   +10 more
europepmc   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Natural history and treatment of asymptomatic unruptured carotid cavernous aneurysms: a systematic review and meta-analysis. [PDF]

Neurol Sci
Trevisi G, Pennisi G, Santi S, Montemurro N, Palermo M, Sturiale CL.   +5 more
europepmc   +1 more source

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source