Results 101 to 110 of about 3,922,331 (297)

Comet and Meteorite Traditions of Aboriginal Australians

open access: yes, 2014
Of the hundreds of distinct Aboriginal cultures of Australia, many have oral traditions rich in descriptions and explanations of comets, meteors, meteorites, airbursts, impact events, and impact craters. These views generally attribute these phenomena to
AWR Bevan   +9 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

How do different student constituencies (not) learn the history and philosophy of their subject? Case studies from science, technology and medicine [PDF]

open access: yes, 2002
[FIRST PARAGRAPH] Why should H.E. teachers concern themselves with how their students do or don’t learn? Much has been said recently about the alleged merits and demerits of ‘student-centred’ learning, especially on the extent to which student ...
Gooday, G.
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Short-Course Chemotherapy for Tuberculosis [PDF]

open access: yes, 2005
Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005. ©The Trustee of the Wellcome Trust,
Christie, DA, Tansey, EM
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Recycling the evidence: different approaches to the reanalysis of gerontological data [PDF]

open access: yes, 2005
In 1991 Professor Margot JEFFERYS and two colleagues interviewed "pioneers of geriatric medicine" of whom 60 were geriatricians. These data are now on disk and can be searched digitally. The interviews were long and focussed on the careers of the doctors
Bornat, Joanna
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The history of varicocele: from antiquity to the modern ERA

open access: yesInternational Brazilian Journal of Urology
Men have most likely been affected by varicocele since the assumption of the upright position. In De Medicina, written during the first century AD, Celsus credits the Greeks with the first description of a varicocele, and he recorded his own acute ...
Antonio Marte
doaj   +1 more source

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