Results 131 to 140 of about 3,922,331 (297)
Early Development of Total Hip Replacement [PDF]
, 2007 Annotated and edited transcript of a Witness Seminar held on 14 March 2006. Introduction by Dr Francis Neary and Professor John Pickstone. First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2007. ©The Trustee of the Wellcome
Reynolds, LA, Tansey, EM
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Art and the Human Condition: Incorporating Visual Analysis of Artworks into a Undergraduate Pre-Medicine Curriculum [PDF]
, 2012 This thesis project presents a sample class session for the course, The Human Condition: An Arts Perpective (ARTH 361), which will be a part of the optional Medical Humanities minor for the pre-medicine students at Virginia Commonwealth University (VCU)
Fuqua, Elizabeth
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Correction to: Making Medical History Relevant to Medical Students: The First Fifty Years of the Calgary History of Medicine Program and History of Medicine Days Conferences. [PDF]
J Hist Med Allied Sci, 2023 europepmc +1 more source
Case History. College of Medicine Yearbook [PDF]
, 1952 1952https://scholarworks.uvm.edu/dmlyearbook/1001/thumbnail ...
University of Vermont
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
"An epoch-making and blessed moment in the history of medicine" -thoughts on international health equity and the Nobel prize in medicine. [PDF]
Int J Equity Health, 2021 Linneman ZM, Satin DJ.
europepmc +1 more source