Results 201 to 210 of about 2,079,515 (256)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

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The fighting for history of medicine

Problems of Social Hygiene Public Health and History of Medicine, 2021
The article considers issues of actual discussion about "death of history of medicine". For a long time, history of medicine was set out the task to substantiate triumph of one national model and tradition over another one and "to place the past at the service of the future". For example, Richard Horton, the editor-in-chief of The Lancet, believes that
E E, Berger, M S, Tutorskaya
openaire   +2 more sources

The Histories of Medicine: Toward an Applied History of Medicine

2013
An exchange familiar to most historians of medicine recently took place at our school of medicine during a discussion about the inclusion of medical history in the curriculum. A committee consisting of academic medical historians and medical faculty active in the local physician-centre d history of medicine society had been established to help ...
Howard I. Kushner, Leslie S. Leighton
openaire   +1 more source

History of Lasers in Medicine

The Thoracic and Cardiovascular Surgeon, 1988
While the history of laser begins in 1951, the first medical application is reported by Goldman in 1962. In cardiovascular surgery McGuff first used a Ruby-Laser in 1963 for the experimental ablation of atherosclerotic plaques. After a long time of investigations and new developments in laser technology first clinical applications were performed by ...
openaire   +3 more sources