Results 261 to 270 of about 2,039,156 (298)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A Brief History of Traditional Indian Medicine: In Particular, Yoga and Siddha Systems of Medicine Part 1 – WHY Indian Medicos Need to Know of the Rich Medical Heritage of Bharat - An Eye-opener

Hiramalini Seshadri, Divya Seshadri
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

FEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar, Michael A. Ripperger, Grant M. Westlake, Kevin C. Ess   +3 more
wiley   +1 more source

History of development of scientific research on veterinary medicine in Yakutia in 1871-1960

М. П. Неустроев, M.M. Cherosov, S.A. Vasilieva   +2 more
openalex   +1 more source

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History of Medicine

Historia medicinae, 2020
for other women to train as nurses by the Red Cross. Their expertise was precious during the famine and cholera epidemics. During the Crimean war, Pirogov pleaded for the establishment of an international treaty to oversee the provision of medical help ...
Yu.P. Lisitsyn
semanticscholar   +1 more source

The effects and underlying mechanisms of medicine and food homologous flowers on the prevention and treatment of related diseases.

Journal of food biochemistry, 2022
The theory of medicine and food homology has a long history in China. Numerous traditional Chinese medicinal could be used as both medicine and food. Many flower medicinal materials also belong to the homology of medicine and food, such as Chrysanthemum ...
Aijinxiu Ma, Fengmao Zou, Ruowen Zhang, Xu Zhao   +3 more
semanticscholar   +1 more source

Radiotheranostics in oncology: Making precision medicine possible

Ca-A Cancer Journal for Clinicians, 2023
Eric Aboagye
exaly