Molecular Oncology, EarlyView.In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim +11 more
wiley +1 more source
De menselijke canon. Het vraagstuk van de ideale mens in de Nederlandse medische wetenschap
BMGN: Low Countries Historical Review, 2007 The human benchmark. The issue of the ideal human being in Dutch medical science In ancient times the sculptor Polycletus constructed a statue representing the most harmonious i.e. beautiful proportions of man, which he named Canon.
C. Santing
doaj
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source
Politics, geopolitics, and the history of science: on James Secord's "Inventing the scientific revolution". [PDF]
Hist Cienc Saude ManguinhosBarahona A +9 more
europepmc +1 more source
ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma
Molecular Oncology, EarlyView.In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee +9 more
wiley +1 more source
Religious Confessions and the Sciences in the Sixteenth Century by Jürgen Helm and Annette Winkelmann edd. [PDF]
Aestimatio, 2004 James T. Robinson
doaj
New Challenges and Perspectives on the Long-Term Study and Curation of the Collection of Identified Human Skeletons Housed at the National Museum of Natural History and Science, Lisbon, Portugal. [PDF]
Am J Biol AnthropolCardoso HFV, Albanese J, Quintino Y.
europepmc +1 more source
Select Documents Illustrative of the History of the United States, I776-I86I. Edited with Notes by WILLIAM MACDONALD, Professor of History and Political Science in Bowdoin College. Pp. xiii, 465. Price, $2.25. New York and London: The Macmillan Company, I898 [PDF]
, 1898 Herman V. Ames
openalex +1 more source