Results 91 to 100 of about 175,139,164 (218)
Reconstructing the invention of the wheel using computational structural analysis and design
Royal Society Open ScienceThe invention of the wheel is widely credited as a pivotal moment in human history, yet the details surrounding its discovery are shrouded in mystery. There remains no scholarly consensus on key questions such as where, how and by whom this technology ...
Lee R. Alacoque +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
, 2001 Thesis (S.M.M.O.T.)--Massachusetts Institute of Technology, Sloan School of Management, Management of Technology Program, 2001.Includes bibliographical references (leaves 134-141).The Internet is changing the way we do business.
Hanantasena, Bayu, 1969- +1 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Blockchain technology in supply chain and logistics
, 2018 Thesis: S.M. in Engineering and Management, Massachusetts Institute of Technology, System Design and Management Program, 2018.Cataloged from PDF version of thesis.Includes bibliographical references (pages 92-99).Blockchain technology is a peer-to-peer ...
Agarwal, Shweta, S.M. Massachusetts Institute of Technology
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Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Modified Maxwell Model for hysteresis compensation of piezoelectric stack actuators
, 2015 Thesis: S.B., Massachusetts Institute of Technology, Department of Mechanical Engineering, 2015.Cataloged from PDF version of thesis.Includes bibliographical references (page 29).This thesis presents new observations of the hysteresis behavior of ...
Xie, Xiaoyue, S.B. Massachusetts Institute of Technology
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Users, systems, and technology in high-end audio [PDF]
, 2009 Thesis (Ph. D. in History, Anthropology, and Science, Technology and Society (HASTS))--Massachusetts Institute of Technology, Program in Science, Technology and Society, 2009.Page 414 blank.Includes bibliographical references (p. 401-413).This is a story
Downes, Kieran
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
L’impératif de la sobriété numérique : enjeux et définitions
Humanités NumériquesThis article outlines the history of digital technology, identifying the main trends at work and documenting their ecological implications. It then draws up an overview of the main regulations at work, and concludes that they have more to do with ...
Fabrice Flipo
doaj +1 more source