Results 71 to 80 of about 175,139,164 (218)

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Wireless Telegraphy at the German Universal Exhibition in Ústí nad Labem in 1903 [1]

open access: yesActa Polytechnica, 2008
This paper focuses on the transmission of wireless telegraphy between Ústí nad Labem and Teplice during the German Universal Exhibition in Ústí nad Labem in 1903.
T. Okurka
doaj  

Techno-Optimism Archive: Technological Optimism, Utopianism, Solutionism, and Hype in the Historical Press

open access: yesJournal of Open Humanities Data
The Techno-Optimism Archive Dataset is a curated collection of historical press examples of technological optimism and techno-solutionist thought. Drawn from dispersed digital archives of newspapers and magazines, it captures recurring promises that ...
Krystian Łukasik
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Commercialization of QD WLED technology

open access: yes, 2006
Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Materials Science and Engineering, 2006.Includes bibliographical references.It is well known that the use of high-brightness LEDs for illumination has the potential to substitute ...
Zhao, Xinyue, M. Eng. Massachusetts Institute of Technology
core  

Syntactic features : parametric variation in the history of English [PDF]

open access: yes, 1987
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Linguistics and Philosophy, 1987.Title as it appears in M.I.T. Graduate List, Sept. 1987: Syntactic features--parameters in the history of English.Bibliography: v. 2, leaves 418-422.by John
Lumsden, John Stewart
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From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Science, technology, engineering, and mathematics workforce crisis or science, technology, engineering, and mathematics workforce surplus

open access: yes, 2014
Thesis: S.M. in Technology and Policy, Massachusetts Institute of Technology, Engineering Systems Division, Technology and Policy Program, 2014.Cataloged from PDF version of thesis.Includes bibliographical references (pages 73-77).The science, technology,
Xue, Yi,Ph. D.Massachusetts Institute of Technology.
core  

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