Results 41 to 50 of about 780,944 (263)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Making the History of Computing. The History of Computing in the History of Technology and the History of Mathematics [PDF]
Revue de Synthèse, 2018 Abstract A history of writing the history of computing is presented in its relationship to the history of mathematics. As with many historiographies, the initial history of computing was very much an internalistic history. In the late 1970s, the field became more serious and started looking at the histories of mathematics and technology for ...
de Mol, Liesbeth, Bullynck, Maarten
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Acta PolytechnicaThe circulation of British engineers in South America during the first half of the twentieth century is a barely explored phenomenon that should be studied in the basis of methodologies that articulate the different elements involved, with the aim of ...
Jorge Alonso Rodríguez Ortiz
doaj +1 more source
The History of Science in Latin America in its own terms
Revista Portuguesa de História, 2020 This article conducts a comparative analysis of two journals: Quipu, created in 1984 by the Latin American Society for the History of Sciences and Technology in Mexico, published until 1994 and shortly relived between 1999 and 2000, and the Brazilian ...
Marcia Regina Barros da Silva
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Beyond Innovation and Use, or Why We Must Follow Technologies through Time
HistoriesSynthesizing various studies that follow technology beyond innovation and use, this article aims to continue widening the scope of history of technology toward this perspective. It argues that we must follow technology through time and—in addition to its
Heike Weber
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source