Results 51 to 60 of about 787,743 (263)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
What Were Bulletin Board Systems? Looking Back At Pre-Internet Online Communication in Turkey
İletişim Kuram ve Araştırma DergisiAs an online communication technology predating the Internet, Bulletin Board Systems (BBSs) are considered to be precursors of modern-day social media. Despite being a popular technology of its era both in Türkiye and abroad, BBS technologies tend to be ...
Ivo Ozan Furman
doaj +1 more source
Self-Writing Machines: Technology and the Question of the Self
communication +1, 2015 In order to show that technology mediates between man and machine, I will discuss in this text a literally other or alter-knowledge system that also heavily relied on self-writing machines: spiritualism.
Christian Kassung
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
How to Activate the Potential of Imaginary Networks
VIEW Journal of European Television History and CultureI explore how imaginary networks provide us with meaningful models for alternative future networks outside of or beyond the internet. This essay mostly looks first at how media archaeology’s interest in uncovering media from the past to reimagine media ...
Lori Emerson
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The Electrification of Tramways in Ostrava in 1900–1901
Acta Polytechnica, 2012 This paper focuses on the electrification of tramways in Ostrava in 1900-1901. As the administrative, economic and cultural centre of an evolving industrial agglomeration, Ostrava had specific transportation requirements.
Michaela Závodná
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Journal for the History of Environment and SocietyThe introduction to this special issue of the Journal for the History of Environment and Society argues that diving has been and remains a crucial practice for experiencing the sea, studying the underwater environment, and exploiting life and resources ...
Eike-Christian Heine
doaj +1 more source
Flourishing tumor organoids: History, emerging technology, and application. [PDF]
Bioeng Transl Med, 2023 Yang Q +7 more
europepmc +1 more source