Results 151 to 160 of about 921,158 (313)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Swinburne University of Technology TAFE Division Prahran campus handbook, 1993
, 1993 Swinburne University of Technology TAFE Division (Prahran Campus) handbook giving general information, course descriptions and subject details for the year ...
Swinburne University of Technology
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Graduate Certificate in Science and Technology, 1995
, 1995 Left-right: Michelle Griffiths, Croydon Hills Primary School; Sandra Farley, South Warrandyte Primary School; and Richard Fly, Nunawading Primary School, first graduates of the Graduate Certificate in Science and Technology with Peter Dunne, the Course ...
Swinburne University of Technology
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Chinese Minister of Science and Technology Wan Gang, 2011
, 2011 Chinese Minister of Science and Technology, Dr Wan Gang during visit to Swinburne University on 24 March, 2011. Photographs appeared in the Media Centre release, 'Swinburne welcomes Chinese minister', on 24 March ...
Swinburne University of Technology
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Why the same herb is not the same medicine: plant epigenetic and metabolic plasticity as a missing variable in Chinese medicine. [PDF]
Chin MedHyun TK.
europepmc +1 more source
Information Technology Investment Planning
, 2016 "Revision history ... 10/13/2016: Revised planning requirements to reflect process updates. In addition, transferred policy content to a new State of Ohio Administrative Policy Template. Re???numbered policy to IT???02 to be consistent with new numbering
Ohio. Office of Information Technology.
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