Results 21 to 30 of about 921,158 (313)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Beyond Innovation and Use, or Why We Must Follow Technologies through Time

open access: yesHistories
Synthesizing various studies that follow technology beyond innovation and use, this article aims to continue widening the scope of history of technology toward this perspective. It argues that we must follow technology through time and—in addition to its
Heike Weber
doaj   +1 more source

Railway photography and technology: analysis of the photographic record of Brazilian railway in the 19th century [PDF]

open access: yesHistória, 2019
The purpose of this text is to examine some sets of photographs about railway companies in Brazil, in order to highlight the potential of this type of iconographic material, not as artistic documentation but also technological documentation.
Eduardo Romero de Oliveira
doaj   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

What Were Bulletin Board Systems? Looking Back At Pre-Internet Online Communication in Turkey

open access: yesİletişim Kuram ve Araştırma Dergisi
As an online communication technology predating the Internet, Bulletin Board Systems (BBSs) are considered to be precursors of modern-day social media. Despite being a popular technology of its era both in Türkiye and abroad, BBS technologies tend to be ...
Ivo Ozan Furman
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

How to Activate the Potential of Imaginary Networks

open access: yesVIEW Journal of European Television History and Culture
I explore how imaginary networks provide us with meaningful models for alternative future networks outside of or beyond the internet. This essay mostly looks first at how media archaeology’s interest in uncovering media from the past to reimagine media ...
Lori Emerson
doaj   +1 more source

Troublesome telephony: how users and non-users shaped the development of early British exchange telephony

open access: yesScience Museum Group Journal, 2015
When exchange telephony was first marketed to the British public by the early telephone companies in the late nineteenth century it was as an intuitive technology requiring no specialist knowledge or training.
Dr Michael Kay
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Electrification of Tramways in Ostrava in 1900–1901

open access: yesActa Polytechnica, 2012
This paper focuses on the electrification of tramways in Ostrava in 1900-1901. As the administrative, economic and cultural centre of an evolving industrial agglomeration, Ostrava had specific transportation requirements.
Michaela Závodná
doaj  

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