Results 41 to 50 of about 815,920 (262)

Alographia dos álkalis... de Frei Conceição Veloso: um manual de química industrial para produção da potassa no Brasil colonial The production of potash from plants in colonial Brazil as described in fray Conceição Veloso's Alographia dos alkalis...

Química Nova, 2008
Potassium carbonate, or potash, was the most important industrial chemical of the 18th century. It was essential for producing glass, soap, saltpeter, dyes, several drugs, and also used for bleaching linens, paper, and sugar.
Fernando J. Luna
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Making the History of Computing. The History of Computing in the History of Technology and the History of Mathematics [PDF]

Revue de Synthèse, 2018
Abstract A history of writing the history of computing is presented in its relationship to the history of mathematics. As with many historiographies, the initial history of computing was very much an internalistic history. In the late 1970s, the field became more serious and started looking at the histories of mathematics and technology for ...
de Mol, Liesbeth, Bullynck, Maarten
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A geopolitics of the diaspora of British engineers in South America in the first half of the 20th century: the cases of the Institution of Locomotive Engineers centre in Argentina

Acta Polytechnica
The circulation of British engineers in South America during the first half of the twentieth century is a barely explored phenomenon that should be studied in the basis of methodologies that articulate the different elements involved, with the aim of ...
Jorge Alonso Rodríguez Ortiz
doaj   +1 more source

The History of Science in Latin America in its own terms

Revista Portuguesa de História, 2020
This article conducts a comparative analysis of two journals: Quipu, created in 1984 by the Latin American Society for the History of Sciences and Technology in Mexico, published until 1994 and shortly relived between 1999 and 2000, and the Brazilian ...
Marcia Regina Barros da Silva
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Beyond Innovation and Use, or Why We Must Follow Technologies through Time

Histories
Synthesizing various studies that follow technology beyond innovation and use, this article aims to continue widening the scope of history of technology toward this perspective. It argues that we must follow technology through time and—in addition to its
Heike Weber
doaj   +1 more source