Results 61 to 70 of about 921,158 (313)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Zagadnienia Filozoficzne w Nauce, 2010 The paper raises the question of why historians of science were never seriously interested in the genesis of optical spectroscope despite the fact that it had played so crucial and decisive role in the development of modern science. It is also noted that
Jacek Rodzeń
doaj
, 2019 Thesis: Ph. D. in History, Anthropology, and Science, Technology and Society (HASTS), Massachusetts Institute of Technology, Program in Science, Technology and Society, 2019Cataloged from PDF version of thesis.Includes bibliographical references (pages ...
Kim, Grace,Ph. D.Massachusetts Institute of Technology.
core
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Flourishing tumor organoids: History, emerging technology, and application. [PDF]
Bioeng Transl Med, 2023 Yang Q +7 more
europepmc +1 more source
Nature, 1955 A History of Technology Edited by Charles Singer, E. J. Holmyard and A. R. Hall; assisted by E. Jaffe, R. H. G. Thomson and J. M. Donaldson. Vol. 1: From Early Times to Fall of Ancient Empires. Pp. lv + 8 maps + 828 + 36 plates. (Oxford: Clarendon Press; London: Oxford University Press, 1954.) £7 7s. net.
openaire +1 more source
Sara Jervis and Derek Whitehead, 50th Anniversary of IBL, 2013
, 2013 Sara Jervis (Coordinator, Swinburne History and Artefacts) and Derek Whitehead (Director, Information Technology Services) at 50th anniversary of Industry Based Learning (IBL) celebrations, ATC Building, Hawthorn Campus, 18 July ...
Swinburne University of Technology
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source