Results 161 to 170 of about 289,724 (344)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Ancient individuals from the North American Northwest Coast reveal 10,000 years of regional genetic continuity

Proceedings of the National Academy of Sciences of the United States of America, 2016
J. Lindo, A. Achilli, U. Perego, David R. Archer, Cristina E. Valdiosera, Cristina E. Valdiosera, Barbara Petzelt, Joycelynn Mitchell, Rosita Worl, E. Dixon, Terence E. Fifield, Terence E. Fifield, M. Rasmussen, M. Rasmussen, E. Willerslev, E. Willerslev, J. Cybulski, J. Cybulski, B. Kemp, Michael Degiorgio, R. Malhi   +20 more
semanticscholar   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Toward a Biocultural Synthesis of the Peopling of the Americas: Introduction to the Special Issue. [PDF]

Am J Biol Anthropol
Menéndez LP, Hubbe M.
europepmc   +1 more source

After Columbus: Explaining the Global Trade Boom 1500-1800 [PDF]

This paper documents the size and timing of the world inter-continental trade boom following the great voyages in the 1490s of Columbus, da Gama and their followers. Indeed, a trade boom followed over the subsequent three centuries.
Jeffrey G. Williamson, Kevin H. O'Rourke
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Evidence for Historic and Ongoing Human-Mediated Dispersal of Yeast. [PDF]

Mol Ecol
Ruffieux M, Smukowski Heil C.
europepmc   +1 more source

Faunal record identifies Bering isthmus conditions as constraint to end-Pleistocene migration to the New World

Proceedings of the Royal Society B: Biological Sciences, 2014
Meirav Meiri, A. Lister, M. Collins, N. Tuross, T. Goebel, S. Blockley, G. Zazula, Nienke L. van Doorn, R. D. Guthrie, G. Boeskorov, G. Baryshnikov, A. Sher, Ian Barnes, Ian Barnes   +13 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

MMS Américas: a regional network for malaria molecular surveillance. [PDF]

Malar J
MMS Américas Network.
europepmc   +1 more source