Results 81 to 90 of about 288,906 (303)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Breve história da hanseníase: sua expansão do mundo para as Américas, o Brasil e o Rio Grande do Sul e sua trajetória na saúde pública brasileira Trajectory in the Brazilian Public Health

open access: yesSaúde e Sociedade, 2004
Este trabalho faz uma revisão sobre a história da hanseníase através dos tempos, desde sua provável origem na Antigüidade até a sua vinda para as Américas, o Brasil e o Rio Grande do Sul.
Letícia Maria Eidt
doaj   +1 more source

From “Greater America” to America’s Music: Gilbert Chase and the Historiography of Borders [PDF]

open access: yes, 2019
This essay considers the hotly debated U.S. border and its relationship to music historiography vis-à-vis the unconventional career of Gilbert Chase (1906-92), the first U.S. musicologist to take seriously the music of the Spanish-speaking world.
Hess, Carol A.
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Postgraduate Prospectus 2006-07 [PDF]

open access: yes, 2005
Outlines degree and course offerings on Latin American Studies, United States Studies and Comparative American Studies in the Institute for the Study of the ...

core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

COLONIAL INSTITUTIONS AND LONG-RUN ECONOMIC PERFORMANCE IN COLOMBIA: IS THERE EVIDENCE OF PERSISTENCE? [PDF]

open access: yes
A recent body of literature has claimed that differences in long-run economic performance within the Americas stem from the different institutional structures established during colonial times.
Camilo García Jimeno
core  

History of the Buccaneers of America

open access: yes, 2010
Captain James Burney (1750–1821), the son of the musicologist Dr Charles Burney and brother of the novelist Fanny Burney, was a well-travelled sailor, best known for A Chronological History of the Discoveries in the South Sea or Pacific Ocean (1803–1817), of which this work formed a part.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Chikungunya Epidemic: A look at five cases

open access: yesIDCases, 2015
Chikungunya is an infection caused by the Chikungunya virus and transmitted by the bite of infected mosquito. The most common symptoms of Chikungunya virus infection are fever, joint pain or rash.
Bethel Shiferaw   +6 more
doaj   +1 more source

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