Results 101 to 110 of about 975 (166)

Integrating Artificial Intelligence Into Drug Discovery From Medicinal Plants: Current Applications and Infrastructural Challenges

open access: yesChemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
This review presents a systems‐oriented roadmap for integrating artificial intelligence into medicinal plant drug discovery to overcome persistent bottlenecks like extract complexity. It highlights that advancing toward reproducible therapeutics requires making phytochemical datasets AI‐ready via rigorous harmonization and phyto‐centric foundational ...
Amit Gangwal   +5 more
wiley   +1 more source

Conservation implications of low contemporary connectivity along the Mid‐Atlantic Ridge in hydrothermal vent gastropods

open access: yesConservation Biology, Volume 40, Issue 4, August 2026.
Abstract Polymetallic sulfide deposits produced at hydrothermal vent fields are targets for mining exploitation along the Mid‐Atlantic Ridge, threatening the functioning and resilience of vent ecosystems that provide multiple ecosystem services. Knowledge about connectivity between vents will inform conservation practices.
E. Portanier   +10 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

open access: yesThe FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy   +7 more
wiley   +1 more source

Machine Learning of Personal Repertoires From Public T Cell Receptors

open access: yesImmunological Reviews, Volume 341, Issue 1, August 2026.
ABSTRACT The T‐cell receptor (TCR) repertoire records an individual's immunological history, but most unique CDR3 sequences in any one person are private and uninformative about anyone else. A small subset, however, recurs predictably across unrelated donors.
Or Malca, Alona Zilberberg, Sol Efroni
wiley   +1 more source

Contrasting Palaeogeographic Histories but Similar Microevolutionary Responses in Low‐Dispersal Island Grasshoppers From Two Mediterranean Archipelagos

open access: yesJournal of Biogeography, Volume 53, Issue 8, August 2026.
ABSTRACT Aim Island archipelagos serve as natural laboratories for understanding how geological history, climate change and dispersal limitation interact to shape diversification. Here, we examine how these forces influence patterns of genomic divergence, demographic dynamics and phenotypic variation in island‐endemic taxa, with a particular focus on ...
Marina Trillo, Joaquín Ortego
wiley   +1 more source

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