Results 31 to 40 of about 975 (166)

Integrated one‐pot CRISPR‐Cas detection: Addressing strategies and future prospects

Interdisciplinary Medicine, EarlyView.
Integrated one‐pot CRISPR‐Cas detection significantly simplifies workflows, reduces cross‐contamination risks, and shortens turnaround times, making it highly suitable for point‐of‐care testing (POCT) and resource‐limited settings. Key challenges include system compatibility issues between Cas proteins and isothermal amplification, limited multiplexing
Jian Zhou, Xuemei Ren, Yingjie Ren, Ruiping Wu, Ruiman Geng, Le Chen, Zhuo Li   +6 more
wiley   +1 more source

Analysis of individualized brain–gut association networks and transcriptional patterns in major depressive disorder

Interdisciplinary Medicine, EarlyView.
Individualized brain–gut association networks suggest potential neuropathological mechanisms in MDD and MDDSI. Multilevel brain–gut association changes involving HSV‐1 and inflammation may be relevant to MDD, whereas alterations related to insulin metabolism may play a potential role in the neuropathological mechanisms of MDDSI.
Wei Wang, Baoyuan Zhu, Yuanyuan Huang, Liqin Liang, Zhaobo Li, Yunheng Diao, Minxin Guo, Heng Zhang, Jing Zhou, Fengchun Wu, Kai Wu   +10 more
wiley   +1 more source

Organizational and Functional Principles of the Obligate Respiratory Chain Supercomplex

Journal of the Chinese Chemical Society, EarlyView.
In this review we deliver a comprehensive structural analysis of the actinobacterial respiratory chain supercomplex and discuss the principles underlying the assembly of its supramolecular architecture. ABSTRACT Proton translocating respiratory chain complexes assemble into supramolecular structures in their native cellular environment, yet the ...
Wei‐Chun Kao, Nick Hiatt, Carola Hunte
wiley   +1 more source

Explicit Dynamics Analysis of the Impact Response of Lithium‐Ion Cells

Macromolecular Symposia, EarlyView.
ABSTRACT It is very important to make sure that EV lithium‐ion cells are safe when they are abused, like when they are hit or crushed. This kind of loading can cause structural failure or thermal runaway. Even though FEA is used a lot, common practices make the jellyroll the same and ignore the fact that the electrolyte is a moving fluid.
Radu‐Ionuț Stoica, Emanuel‐Eduard Zencenco, Gabriel‐Dumitru Smaranda   +2 more
wiley   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Gene turnover in the common ancestor of all C4 grasses

PLANTS, PEOPLE, PLANET, EarlyView.
Understanding how plants evolve more efficient photosynthesis is important in a warming world where improving crop productivity and resilience is a global priority. By generating the first reference genomes for an early‐diverging group of grasses called the Aristidoideae, we were able to reconstruct the genetic makeup of the last common ancestor of all
Lara Pereira, Ahmed S. Alenazi, Sahr Mian, Ilia J. Leitch, Pascal‐Antoine Christin, Colin P. Osborne, Luke T. Dunning   +6 more
wiley   +1 more source

A Functional Flows Framework for the Terminal Great Salt Lake Basin: Can We Have Our Lake and Drink It Too?

River Research and Applications, EarlyView.
ABSTRACT Terminal basins provide unique aquatic environments that are often highly sensitive to streamflow contributions, making them a focal point for environmental water management. However, the water needs for terminal lake, wetland, and river ecosystems, and how they relate, remain a fundamental knowledge gap that constrains our ability to ...
Belize Lane, Melissa Stamp, Sarah E. Null, Paul Thompson, Jeffrey Ostermiller, Farah Nusrat, Noelle Patterson, Maddie Witte, Bethany Neilson, Michelle Baker   +9 more
wiley   +1 more source

Navigating Classical and Nonclassical Realms of Nucleation and Crystallization

Small, EarlyView.
Classical nucleation and growth theories have long been foundational, yet recent nonclassical concepts have challenged and refined our understanding of solid‐state genesis. This paradigm shift introduced new, often ambiguous vocabulary. Here, we clarify key concepts, correct common misconceptions, and provide a terminological field guide across systems,
Stephan E. Wolf, Peter G. Vekilov
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

SFK: Shape‐ and Function‐Grounded Keypoint Representation for Sequential Manipulation

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Sequential manipulation is the process by which robots perform multiple interdependent steps to accomplish composite tasks, demanding tight integration of perception, planning and execution. Existing methods incorporate explicit features such as category, semantics, 6D pose or affordance to enhance consistency, yet single‐feature ...
Yaxin Liu, Yan Liu, Xinyu Song, Ruiqing Han, Haiyong Liu, Bo Huang, Yufeng Yao, Ming Zhong   +7 more
wiley   +1 more source