Results 111 to 120 of about 562,363 (310)

New Hits

open access: yes, 2014
Cover for New Hits, from the RISD Library Zine Collection.https://digitalcommons.risd.edu/specialcollections_zinecollection/2036/thumbnail ...
Collections, Special   +2 more
core   +1 more source

Big hits, export concentration and volatility

open access: yes, 2015
Recent empirical work has documented the high concentration of trade flows, and the large role played by few “big hits” in each country’s export. We propose a simple stochastic benchmark against which we assess each economy’s actual number of “big hits”.
Sufrauj, Shamnaaz B.   +4 more
core   +1 more source

CO2 on Graphene: Benchmarking Computational Approaches to Noncovalent Interactions

open access: yesACS Omega, 2023
Christopher Ehlert   +2 more
doaj   +1 more source

A South African perspective on factors that impact on the adoption and meaningful use of health information technologies

open access: yesSouth African Family Practice, 2013
Objective: Various benefits are associated with the adoption and meaningful use of health information technologies (HITs) in the healthcare sector. Despite the associated advantages with the adoption and use of HITs, the South African healthcare sector ...
N. Mostert-Phipps, D. Pottas, M. Korpela
doaj   +1 more source

Discovery of New Anti-Schistosomal Hits by Integration of QSAR-Based Virtual Screening and High Content Screening

open access: yesJournal of Medicinal Chemistry, 2016
Schistosomiasis is a debilitating neglected tropical disease, caused by flatworms of Schistosoma genus. The treatment relies on a single drug, praziquantel (PZQ), making the discovery of new compounds extremely urgent.
B. Neves   +15 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

ROC curves of hits from SCOP 40 to itself.

open access: yes, 2013
Hits to the same SCOP classification are considered true positives, hits with different classifications are considered false positives.
Tomasz Furmanek (283506)   +1 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Episodic memory assessment: effects of sex and age on performance and response time during a continuous recognition task

open access: yesFrontiers in Human Neuroscience
IntroductionContinuous recognition tasks (CRTs) assess episodic memory (EM), the central functional disturbance in Alzheimer’s disease and several related disorders.
James O. Clifford   +9 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

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