Results 101 to 110 of about 430,069 (325)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

First Hitting Times on a Quantum Computer: Tracking vs. Local Monitoring, Topological Effects, and Dark States

open access: yesEntropy
We investigate a quantum walk on a ring represented by a directed triangle graph with complex edge weights and monitored at a constant rate until the quantum walker is detected.
Qingyuan Wang   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Trajectory prediction model for crossing-based target selection

open access: yesVirtual Reality & Intelligent Hardware, 2019
Background Crossing-based target selection motion may attain less error rates and higher interactive speed in some cases. Most of the research in target selection fields are focused on the analysis of the interaction results.
Hao ZHANG   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Enhanced boxing punch impact with silicone cushioning

open access: yesFrontiers in Sports and Active Living
IntroductionElastic cushioning materials protect human tissue from injury by absorbing impact energy and delaying its transfer. However, the potential compromise in force delivery to the hitting target remains unknown.MethodsTo examine if silicone ...
Sirichet Punthipayanon   +5 more
doaj   +1 more source

Oil-based maintenance interval optimization for power-shift steering transmission

open access: yesAdvances in Mechanical Engineering, 2018
The concentration of micron-size particles in used oil is generally obtained by atomic emission spectrometry. These accurate results can be considered as the most important index for real-time reliability evaluation including failure prediction and ...
Changsong Zheng   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy