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Nature Reviews Disease Primers, 2015 More than 75 million people worldwide have been infected with human immunodeficiency virus (HIV), and there are now approximately 37 million individuals living with the infection. Untreated HIV replication causes progressive CD4(+) T cell loss and a wide range of immunological abnormalities, leading to an increased risk of infectious and oncological ...
Steven G, Deeks +3 more
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Viruses, 2021 By the middle of 2021, we are still immersed in the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Carmen María González-Domenech +5 more
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Frontiers in Immunology, 2021 IntroductionFunctional cure has been proposed as an alternative to lifelong antiretroviral therapy and therapeutic vaccines represent one of the most promising approaches.Materials and MethodsWe conducted a double-blind randomized placebo-controlled ...
Lorna Leal +66 more
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Frontiers in Immunology, 2022 Interactions between T follicular helper (Tfh) cells and germinal center B cells are essential for the differentiation of B cells and specific antibody responses against HIV-1 infection.
Xiaofan Lu +14 more
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BMC Infectious Diseases, 2021 Background Uptake of HIV self-tests (HIVST) remains low in Europe. We conducted two separate surveys to understand facilitators and barriers to the use of HIVST in two European countries, as part of the EU INTEGRATE Joint Action.
Sophie G. Nash +8 more
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Chinese Medical Journal, 2023 . Background:. T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibition motif domains (TIGIT), an inhibitory receptor expressed on T cells, plays a dysfunctional role in antiviral infection and antitumor activity.
Junyan Jin +15 more
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Latent tuberculosis screening and treatment in HIV: highly acceptable in a prospective cohort study
ERJ Open Research, 2022 Background People living with HIV (PLWH) are at increased risk of re-activation of latent tuberculosis infection (LTBI). Although UK and international guidelines identify this group as a priority for LTBI screening and treatment, data on attitudes of ...
Helena A. White +8 more
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Targeting the HIV reservoir: chimeric antigen receptor therapy for HIV cure
Chinese Medical Journal, 2023 . Although antiretroviral therapy (ART) can reduce the viral load in the plasma to undetectable levels in human immunodeficiency virus (HIV)-infected individuals, ART alone cannot completely eliminate HIV due to its integration into the host cell genome ...
Shuang Li +6 more
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Current HIV/AIDS Reports, 2004 Primary HIV infection refers to the events surrounding acquisition of HIV infection. It is associated with a nonspecific clinical syndrome that occurs 2 to 4 weeks after exposure in 40% to 90% of individuals acquiring HIV. Patients identified before seroconversion often have very high plasma HIV RNA titers that, without treatment, gradually decrease to
Joanne, Stekler, Ann C, Collier
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Paediatric HIV infection [PDF]
Archives of Disease in Childhood, 1997 Globally paediatric HIV infection represents a major setback to child health. The World Health Organisation estimates that over 20 million adults and 1.5 million children have been infected with HIV since the pandemic began 20 years ago. World wide over a thousand children a day are born with HIV.
M, Sharland +4 more
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