Results 121 to 130 of about 726,640 (329)

CD20+FCRL4+ B Cells Activate CD8+ T Cells via MHC‐I Restriction in Nasopharyngeal Carcinoma Anti‐Tumor Immunity

Advanced Science, EarlyView.
CD20⁺FCRL4⁺ B cells in nasopharyngeal carcinoma actively cross‐present exogenous tumor antigens via MHC‐I, enhancing CD8⁺ T‐cell activation, memory formation, and cytotoxicity. IFNγ‐driven WDFY4 upregulation facilitates this process. These findings reveal an unconventional B‐cell–mediated antitumor mechanism and indicate potential relevance to ...
Benjian Zhang, Xiaotian Yuan, Kelei Gao, Bo You, Yaxuan Wang, Lai Meng, Zirong Chen, Shaobing Xie, Yunqing Liu, Zijian Dong, Shumin Xie, Ruohao Fan, Fengjun Wang, Junyi Zhang, Zhihai Xie, Yongzhen Mo, Hua Zhang, Weihong Jiang   +17 more
wiley   +1 more source

Frailty transitions, inflammation, and mortality among persons aging with HIV infection and injection drug use

, 2020
Damani A. Piggott, Karen Bandeen‐Roche, Shruti H. Mehta, Todd T. Brown, Huanle Yang, Jeremy Walston, Sean X. Leng, Gregory D. Kirk   +7 more
openalex   +2 more sources

Induction and maintenance therapy with intermittent interleukin-2 in HIV-1 infection [PDF]

, 2004
Claire E. Farel, Doreen Chaitt, Barbara Hahn, Jorge A. Tavel, Joseph A. Kovacs, Michael A. Polis, Henry Masur, Dean Follmann, H. Clifford Lane, Richard T. Davey   +9 more
openalex   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

HIV-Tat upregulates the expression of senescence biomarkers in CD4+ T-cells

Frontiers in Immunology
IntroductionCurrent antiretroviral therapy (ART) for HIV infection reduces plasma viral loads to undetectable levels and has increased the life expectancy of people with HIV (PWH).
Víctor Casanova, Víctor Casanova, Andrea Rodríguez-Agustín, Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Elisa Moraga, María José Maleno, Josep Mallolas, Josep Mallolas, Josep Mallolas, Esteban Martínez, Esteban Martínez, Esteban Martínez, Esteban Martínez, Sonsoles Sánchez-Palomino, Sonsoles Sánchez-Palomino, Sonsoles Sánchez-Palomino, José M. Miró, José M. Miró, José M. Miró, José M. Miró, José Alcamí, José Alcamí, José Alcamí, José Alcamí, Núria Climent, Núria Climent, Núria Climent   +27 more
doaj   +1 more source

Sustained-release Griffithsin nanoparticle-fiber composites against HIV-1 and HSV-2 infections

, 2020
Kevin M. Tyo, Amanda B. Lasnik, Longyun Zhang, Mohamed Y. Mahmoud, Alfred B. Jenson, Joshua L. Fuqua, Kenneth E. Palmer, Jill M. Steinbach-Rankins   +7 more
openalex   +2 more sources

Prevalence of Oral Candida Albicans Infection in HIV Sero-Positive Patients in Abakaliki [PDF]

, 2013
E. C. Okonkwo
openalex   +1 more source

Frequency and Significance of HIV Infection among Patients Diagnosed with Thrombotic Thrombocytopenic Purpura [PDF]

, 2017
Background. Case series of patients with a diagnosis of thrombotic thrombocytopenic purpura (TTP) have reported different frequencies of human immunodeficiency virus (HIV) infection; some series suggest that HIV infection may cause TTP. Methods.
Benjamin, Melody, Dezube, Bruce J., George, James N., Kremer Hovinga, Johanna A., Lämmle, Bernhard, Terrell, Deirdra R., Vesely, Sara K., Voskuhl, Gene W.   +7 more
core  

The effect of distance to health-care facilities on childhood mortality in rural Burkina Faso.

, 2011
This study aims to investigate the relation between distance to health facilities, measured as continuous travel time, and mortality among infants and children younger than 5 years of age in rural Burkina Faso, an area with low health facility density ...
Akello, Al-Taiar, Ali Sié, Anja Schoeps, Anyamele, Armstrong Schellenberg, Armstrong Schellenberg, Becher, Becher, Byass, Dambach, Declaration of Alma-Ata, Feikin, Heiko Becher, Jani, Kiwanuka, Louis Niamba, Magnani, Moïsi, Müller, Noor, O'Meara, Royston, Rutherford, Rutherford, Sabine Gabrysch, Sankoh, Sankoh, Sanou, Sié, Van de Poel, Van den Broeck, Wei   +32 more
core   +1 more source

Boron Nitride Nanomaterials Trigger Immunomodulatory Effects in Human Broncho‐Epithelial Cells by Modulating Eicosanoid Lipid Signaling

Advanced Science, EarlyView.
This study demonstrates that BNNT exposure disrupts lipid homeostasis in bronchial epithelial cell cultures and activates eicosanoid lipid biosynthesis, producing inflammatory lipid mediators like leukotrienes. These effects are more pronounced in asthmatic cell cultures compared to healthy ones.
Govind Gupta, Jonas Bossart, Sènan Mickael D'Almeida, Luis Augusto Visani de Luna, Christoph Schwärzler, Tingting Fu, Vanesa Ayala‐Nunez, Alexander Gogos, Marija Buljan, Vera M Kissling, Emmanuel Flahaut, Miguel Garcia, Cyrill Bussy, Peter Wick, Tina Buerki‐Thurnherr   +14 more
wiley   +1 more source