Results 41 to 50 of about 726,640 (329)

HIV infection is associated with elevated biomarkers of immune activation in Ugandan adults with pneumonia. [PDF]

, 2019
IntroductionPneumonia is an important cause of morbidity and mortality in persons living with human immunodeficiency virus (HIV) infection. How immune activation differs among HIV-infected and HIV-uninfected adults with pneumonia is unknown.MethodsThe ...
Byanyima, Patrick, Chang, Emily G, Crothers, Kristina, Davis, J Lucian, Huang, Laurence, Hunt, Peter W, Kaswabuli, Sylvia, Lalitha, Rejani, Lederman, Michael M, Lin, Jue, Moisi, Daniela, Moore, Julia, Musisi, Emmanuel, Sanyu, Ingvar, Sessolo, Abdulwahab, Wang, Richard J, Worodria, William   +16 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Association between ethnicity and migration status with the prevalence of single and multiple long-term conditions in UK healthcare workers

BMC Medicine, 2023
Background Healthcare workers’ (HCW) well-being has a direct effect on patient care. However, little is known about the prevalence and patterns of long-term medical conditions in HCWs, especially those from ethnic minorities.
Winifred Ekezie, Christopher A. Martin, Rebecca F. Baggaley, Lucy Teece, Joshua Nazareth, Daniel Pan, Shirley Sze, Luke Bryant, Katherine Woolf, Laura J. Gray, Kamlesh Khunti, Manish Pareek, on behalf of the UK-REACH study collaborative group   +12 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Increased mortality among Indigenous persons during and after release from prison in New South Wales

Australian and New Zealand Journal of Public Health, 2012
Objective: To estimate the overall and cause specific mortality of Aboriginal offenders in New South Wales (NSW), Australia. Methods: The study cohort consisted of all Aboriginal men and women aged 18 years and older who had experienced full‐time ...
Azar Kariminia, Tony Butler, Jocelyn Jones, Matthew Law   +3 more
doaj   +1 more source

HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load

Cell Reports, 2020
Summary: HIV infection predisposes latent tuberculosis-infected (LTBI) subjects to active TB. This study is designed to determine whether HIV infection of LTBI subjects compromises the balanced Mycobacterium tuberculosis (Mtb)-specific T helper 17 (Th17)
Srabanti Rakshit, Nitin Hingankar, Shuba Varshini Alampalli, Vasista Adiga, Bharath K. Sundararaj, Pravat Nalini Sahoo, Greg Finak, Anto Jesuraj Uday Kumar J, Chirag Dhar, George D’Souza, Rashmi Govind Virkar, Manisha Ghate, Madhuri R. Thakar, Ramesh S. Paranjape, Stephen C. De Rosa, Tom H.M. Ottenhoff, Annapurna Vyakarnam   +16 more
doaj   +1 more source

The epidemiology of HIV infection in Zambia [PDF]

, 2008
Population surveys of health and fertility are an important source of information about demographic trends and their likely impact on the HIV/AIDS epidemic.
Cappuccio, Francesco, Ji, Chen, Kandala, Ngianga-Bakwin, Stones, R. Willliam   +3 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Defining characteristics of nodal disease on PET/CT scans in patients with HIV-positive and -negative locally advanced cervical cancer in South Africa [PDF]

, 2019
Literature reports increased FDG nodal uptake in HIV-positive patients. Our aim is to identify differences in presentation and characteristics of FDG-avid lymph nodes between HIV-positive and HIV-negative locally advanced cervical cancer (LACC) patients ...
Ayeni, Olusegun Akinwale, Baeyens, Ans, Kotzen, Jeffrey Allan, Minnaar, Carrie Anne, Vangu, Mboyo-Di-Tamba   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source