Results 81 to 90 of about 639,534 (344)

Acute Human Immunodeficiency Virus Syndrome Presenting with Hemophagocytic Lymphohistiocytosis [PDF]

, 2008
Hemophagocytic lymphohistiocytosis (HLH) has been described in patients with advanced stages of human immunodeficiency virus (HIV) infection, but rarely occurs during the seroconversion stage of acute HIV infection. We report a case of acute HIV syndrome
Aricò, Bhatia, Castilletti, Costello, Dong-Hyeon Shin, Grateau, Henter, Ho-Sung Yu, Jong-Hee Shin, Jung, Kyung-Hwa Park, Lim, Niedt, Norris, Pantaleo, Shin, Sook-In Jung, Sproat, Sun, Tiab, Tsuda, Verbsky   +21 more
core   +2 more sources

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

Advanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak, Shivananda Kandagalla, Ramesh Sistla   +2 more
wiley   +1 more source

Interleukin-27 is differentially associated with HIV viral load and CD4+ T cell counts in therapy-naïve HIV-mono-infected and HIV/HCV-co-infected Chinese. [PDF]

PLoS ONE, 2014
Human Immunodeficiency Virus (HIV) infection and the resultant Acquired Immunodeficiency Syndrome (AIDS) epidemic are major global health challenges; hepatitis C virus (HCV) co-infection has made the HIV/AIDS epidemic even worse.
Lai He, Jin Zhao, Maggie Haitian Wang, Kenny K Y Siu, Yong-Xia Gan, Lin Chen, Benny C Y Zee, Li Yang, Hsiang-Fu Kung, Zheng-Rong Yang, Ming-Liang He   +10 more
doaj   +1 more source

Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. [PDF]

, 1993
Infection with the human immunodeficiency virus (HIV) results in immunosuppression and depletion of circulating CD4+ T cells. Since the thymus is the primary organ in which T cells mature it is of interest to examine the effects of HIV infection in this ...
Adelsberger, J, Baseler, M, Bonyhadi, M, Boone, E, Justement, JS, Kaneshima, H, McCune, JM, Orenstein, J, Stanley, SK, Sullivan, M   +9 more
core  

HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression [PDF]

, 2011
Background Thymic function is altered in HIV infection and characterized by dysregulation of the thymic epithelial network, reduced thymic output and ultimately an impaired naïve T-cell pool.
A Benoit, A Pandey, A Puel, A Vranjkovic, AM Crawley, AM Crawley, AP Kourtis, B Rethi, C Pallard, Charlene D Young, D David, DC Douek, DL Sodora, GN Gaulton, H Okazaki, J Huang, J Kang, JF Camargo, JH Colle, JH Colle, JJ Peschon, Jonathan B Angel, JT Barata, JT Tan, KA Chambers, KJ Hare, KS Schluns, L Chene, M Kryworuchko, M Paiardini, M Rosenzweig, NK Vudattu, PA MacPherson, Q Jiang, R Hofmeister, SA Koesters, SK Durum, SK Stanley, T Sudo, TA Moore, TJ Fry, TJ Fry, VV Joshi   +42 more
core   +2 more sources

Sustained Vaccine Exposure Elicits More Rapid, Consistent, and Broad Humoral Immune Responses to Multivalent Influenza Vaccines

Advanced Science, EarlyView.
This work presents an injectable polymer‐nanoparticle hydrogel depot platform for delivering multivalent influenza vaccines which induces stronger and more durable immune responses. The technology provides broader protection, including against heterologous and potential pandemic strains (H5N1, H7N9, H9N2), and enhances the effectiveness of commercial ...
Olivia M. Saouaf, Ben S. Ou, Ye Eun Song, Joshua J. Carter, Jerry Yan, Carolyn K. Jons, Christopher O. Barnes, Eric A. Appel   +7 more
wiley   +1 more source

Changes in the cervicovaginal microbiota composition of HPV16‐infected patients after clinical treatment

Cancer Medicine, Volume 11, Issue 24, Page 5037-5049, December 2022., 2022
This study interpreted the differential profiles of cervicovaginal microbiota and CSTs between HC women and HPV16‐infected women with CIN I, CIN II/III or SCC. The relationship between HPV16 clearance and cervicovaginal microbiota composition in each disease stage before and after clinical treatments was also established.
Chao Li, Zhenbo Zhang, Yixia Yang, Hong Liao   +3 more
wiley   +1 more source

Evaluating the effectiveness of a multi-component intervention on early childhood development in paediatric HIV care and treatment programmes: a randomised controlled trial

BMC Pediatrics, 2018
Background HIV infection in a family may affect optimum child development. Our hypothesis is that child development outcomes among HIV-exposed infants will be improved through a complex early childhood stimulation (ECS) programme, and income and loans ...
R. Chingono, H. Mebrahtu, Z. Mupambireyi, V. Simms, H. A. Weiss, P. Ndlovu, F. Charasika, M. Tomlinson, L.D. Cluver, F. M. Cowan, L. Sherr   +10 more
doaj   +1 more source

Basic Principles of Nutrition, HIV and AIDS: Making Improvements in Diet to Enhance Health [PDF]

, 2019
The relationships among nutritional status, infectious diseases and immune system suggest nutrition as a cofactor in human immunodeficiency virus (HIV) progression.
Enwereji, Ezinna E., Ezeama, Martina C., Onyemachi, Prince E.N.   +2 more
core   +1 more source

T‐Cell‐Dependent Bispecific IgGs Protect Aged Mice From Lethal SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
This study describes the development of spike‐targeting T‐cell‐dependent bispecific full‐length human immunoglobulin Gs with enhanced efficacy in the treatment of COVID‐19. The significance of T‐cell‐based immunity during infection is highlighted. These results have significant implications for better clinical effectiveness of therapies for COVID‐19 ...
Wenyan Fu, Wei Zhang, Zhongshuai You, Guangyao Li, Chuqi Wang, Changhai Lei, Jian Zhao, Jin Hou, Shi Hu   +8 more
wiley   +1 more source