Results 321 to 330 of about 2,775,555 (408)

Assessing Gaps in Integrated HIV and STI Testing Among New York State-Funded Providers by Pre-exposure Prophylaxis Status: Implications for Status-Neutral Programming. [PDF]

J Acquir Immune Defic Syndr
Tesoriero JM, Boos EM, Adamashvili N, Massaroni R, Maglaperidze T, O'Grady TJ.   +5 more
europepmc   +1 more source

Immunological and Toxicological Assessment of Triterpenoid Saponins Bearing Lewis‐X‐ and QS‐21‐Based Trisaccharides

Chemistry – A European Journal, Accepted Article.
The search for safer and more effective vaccine adjuvants has intensified in recent years, with triterpenoid saponins like QS‐21 and its analogues emerging as promising candidates. We report the synthesis of a novel QS‐21 analogue featuring betulinic acid as aglycone, a lupane‐type triterpenoid with low toxicity derived from white birch bark.
Oscar Javier Gamboa Marin, Yasmine Adda-Bouchard, Balla Sylla, Nitish Verma, Tania Charpentier, Maya Huber, Guillaume Lopez, André Pichette, Alain Lamarre, Charles Gauthier   +9 more
wiley   +1 more source

Disclosure of positive HIV status to sexual partners among young people receiving treatment at an urban clinic, Kampala, Uganda. [PDF]

AIDS Res Ther
Mugerwa M, Namutundu J, Nangendo J, Babirye Tumusiime V, Ndekezi D, Atuheire CGK, Bwambale K, Kiwanuka SN, Kyaddondo D.   +8 more
europepmc   +1 more source

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

Cytoskeleton, EarlyView.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith, Srinivas Chakravarthy, Amit Rahi, Manas Chakraborty, Kristen M. Vosberg, Marco Tonelli, Maximilian G. Plach, Arabela A. Grigorescu, Joseph E. Curtis, Dileep Varma   +9 more
wiley   +1 more source

Newly designed amplicons-based method for near-full-length genome (NFLG) sequencing of HIV-1 group M recombinant forms. [PDF]

Mol Biol Rep
Moscona R, Wagner T, Geva M, Bucris E, Erster O, Zuckerman NS, Mor O.   +6 more
europepmc   +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

ChemMedChem, EarlyView.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno, Noriho Sakamoto, Hideki Hayashi, Tsutomu Fukuda, Yoshiko Akiyama, Chiaki Iketani, Ritsuko Murakami, Takatomo Tokito, Takuto Miyamura, Hirokazu Yura, Takashi Kido, Hiroshi Ishimoto, Shinnosuke Takemoto, Takahiro Takazono, Tomoya Nishino, Yuji Ishimatsu, Jun Ishihara, Kohsuke Takeda, Yoshimasa Tanaka, Hiroshi Mukae   +19 more
wiley   +1 more source

PP 3.17 – 00211 Genetic Diversity of HIV-1 Long Terminal Repeat in Proviral Populations During Long-Term Antiretroviral Therapy

Journal of Virus Eradication, 2022
T. Nguyen, M.E. Zipparo, L. Adams, A. Glassey, E. Madeen, U. Santamaria, C.A. Rehm, J. Earhart, C.Y. Lau, F. Maldarelli   +9 more
doaj  

Prevalence of HIV/syphilis co-infection among men who have sex with men in China: a systematic review and meta-analysis. [PDF]

BMC Public Health
Su R, Liu Y, Shan D, Li P, Ge L, Li D.
europepmc   +1 more source

Corrin Ring Modification in Peptide Drug Development – a Brief History of “Corrination”

ChemMedChem, EarlyView.
This review highlights the applications of vitamin B12 conjugation (“corrination”) to peptides in the field of peptide‐based therapeutics, focusing on improved physio‐chemical properties, targeted/localized drug delivery, and enhanced oral bioavailability.
Nancy Cham, Robert P. Doyle
wiley   +1 more source