Results 331 to 340 of about 2,775,555 (408)

PP 1.23 – 00130 Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir

open access: yesJournal of Virus Eradication, 2022
L. Lambrechts   +7 more
doaj  

An Efficient Solid‐Phase Synthetic Approach to Prepare TACN‐Functionalized Peptides

open access: yesChemistry–Methods, EarlyView.
By recruiting fluorescent dye NBD as a protecting group, Bis‐NBD‐NO1A is developed as a universal building block to functionalize peptides with TACN derivatives via SPPS. The protection of TACN with NBD becomes the first example to functionalize TACN in a controllable manner. The colour‐guided deprotection of NBD enables further elaborations of TACN as
Yik‐Hoi Yeung   +8 more
wiley   +1 more source

Advances in Isotope Labeling for Solution Nucleic Acid NMR Spectroscopy

open access: yesChemPlusChem, Accepted Article.
The availability of nucleic acid structural biology methods still lags behind that of proteins, as evidenced by the significantly smaller number of structures deposited in the PDB. The highly skewed ratio of nucleic acid structures, relative to their protein counterparts (~1:50), is inverted with respect to the cellular output of RNA and proteins in ...
Stefan Hilber   +3 more
wiley   +1 more source

The Global HIV/AIDS Vaccine Enterprise: scientific strategic plan.

open access: yesPLoS Medicine, 2005
Global HIV/AIDS Vaccine Enterprise
doaj   +1 more source

Inhibition of OATP1B1/3 Rather Than UGT1A1 May Be the Major Cause of the Bilirubin Elevation After Atazanavir Administration

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Atazanavir has been reported to increase total serum bilirubin level up to ninefold. It is widely believed that the observed total bilirubin elevation is primarily due to UGT1A1 inhibition. However, UGT enzymes are well‐known as a low‐affinity and high‐capacity system, and the observed drug–drug interaction mediated by UGTs is usually less than twofold.
Jin Dong   +8 more
wiley   +1 more source

Comparison of HIV prevention indicators among adolescent girls and young women in DREAMS and non-DREAMS intervention districts in Uganda. [PDF]

open access: yesPLoS One
Namuwenge N   +10 more
europepmc   +1 more source

Dose Determinations at Drug Approval Reviews: FDA‐Approved Drugs in Past 5 Years

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Drug dose appropriateness is one of the most discussed issues in regulatory reviews. We analyzed dose determinations during Food and Drug Administration (FDA) drug reviews to determine whether there were changes between the proposed and approved doses of new molecular entities (NMEs), including cases where postmarketing dose‐finding studies were ...
Sachiko Mita, Shunsuke Ono
wiley   +1 more source

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