Results 41 to 50 of about 4,520,848 (313)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Increased mortality among Indigenous persons during and after release from prison in New South Wales

Australian and New Zealand Journal of Public Health, 2012
Objective: To estimate the overall and cause specific mortality of Aboriginal offenders in New South Wales (NSW), Australia. Methods: The study cohort consisted of all Aboriginal men and women aged 18 years and older who had experienced full‐time ...
Azar Kariminia, Tony Butler, Jocelyn Jones, Matthew Law   +3 more
doaj   +1 more source

HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load

Cell Reports, 2020
Summary: HIV infection predisposes latent tuberculosis-infected (LTBI) subjects to active TB. This study is designed to determine whether HIV infection of LTBI subjects compromises the balanced Mycobacterium tuberculosis (Mtb)-specific T helper 17 (Th17)
Srabanti Rakshit, Nitin Hingankar, Shuba Varshini Alampalli, Vasista Adiga, Bharath K. Sundararaj, Pravat Nalini Sahoo, Greg Finak, Anto Jesuraj Uday Kumar J, Chirag Dhar, George D’Souza, Rashmi Govind Virkar, Manisha Ghate, Madhuri R. Thakar, Ramesh S. Paranjape, Stephen C. De Rosa, Tom H.M. Ottenhoff, Annapurna Vyakarnam   +16 more
doaj   +1 more source

Screening for HIV Infection: US Preventive Services Task Force Recommendation Statement.

Journal of the American Medical Association (JAMA), 2019
Importance Approximately 1.1 million persons in the United States are currently living with HIV, and more than 700 000 persons have died of AIDS since the first cases were reported in 1981.
D. Owens, K. Davidson, A. Krist, M. Barry, M. Cabana, A. Caughey, S. Curry, Chyke A Doubeni, J. Epling, Martha Y. Kubik, C. Landefeld, C. Mangione, L. Pbert, Michael Silverstein, M. Simon, Chien-Wen Tseng, J. Wong   +16 more
semanticscholar   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial

The Lancet, 2016
Summary Background Randomised placebo-controlled trials have shown that daily oral pre-exposure prophylaxis (PrEP) with tenofovir–emtricitabine reduces the risk of HIV infection.
S. McCormack, D. Dunn, M. Desai, D. Dolling, M. Gafos, R. Gilson, A. Sullivan, A. Clarke, I. Reeves, G. Schembri, N. Mackie, C. Bowman, C. Lacey, V. Apea, M. Brady, J. Fox, Stephen Taylor, S. Antonucci, S. Khoo, J. Rooney, A. Nardone, M. Fisher, A. Mcowan, A. Phillips, Anne M Johnson, B. Gazzard, O. N. Gill   +26 more
semanticscholar   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

IgA Targeting Human Immunodeficiency Virus-1 Envelope gp41 Triggers Antibody-Dependent Cellular Cytotoxicity Cross-Clade and Cooperates with gp41-Specific IgG to Increase Cell Lysis

Frontiers in Immunology, 2018
The protective efficacy of human immunodeficiency virus-1 (HIV-1) antibodies (Abs) remains mostly correlated with their in vitro neutralizing activity engaging their Fab region.
Maxence Duchemin, Maxence Duchemin, Maxence Duchemin, Marwa Khamassi, Marwa Khamassi, Marwa Khamassi, Lin Xu, Lin Xu, Lin Xu, Daniela Tudor, Daniela Tudor, Daniela Tudor, Morgane Bomsel, Morgane Bomsel, Morgane Bomsel   +14 more
doaj   +1 more source

Microbial translocation is a cause of systemic immune activation in chronic HIV infection

Retrovirology, 2006
Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology remains obscure.
J. Brenchley
semanticscholar   +1 more source

Deep Learning–Assisted Differentiation of Four Peripheral Neuropathies Using Corneal Confocal Microscopy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peripheral neuropathies contribute to patient disability but may be diagnosed late or missed altogether due to late referral, limitation of current diagnostic methods and lack of specialized testing facilities. To address this clinical gap, we developed NeuropathAI, an interpretable deep learning–based multiclass classification ...
Chaima Ben Rabah, Ioannis N. Petropoulos, Mark Stettner, Maryam Ferdousi, Uazman Alam, Nathan Efron, Ahmed Serag, Rayaz A. Malik   +7 more
wiley   +1 more source