Results 281 to 285 of about 207,470 (285)

Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.

Biochemistry, 1990
Primer and dNTP recognition by purified HIV reverse transcriptase have been investigated. Earlier kinetic studies suggested that the reaction pathway for DNA synthesis is ordered, with template-primer and free enzyme combining to form the first complex ...
P. Kedar, J. Abbotts, Teréz Kovács, K. Lesiak, P. Torrence, Samuel H. Wilson   +5 more
semanticscholar   +1 more source

Stepwise mechanism of HIV reverse transcriptase: primer function of phosphorothioate oligodeoxynucleotide.

Biochemistry, 1989
Primer recognition by purified HIV reverse transcriptase has been investigated. Earlier we found that the reaction pathway for DNA synthesis is ordered, with template-primer and free enzyme combining to form the first complex in the reaction sequence ...
C. Majumdar, C. Stein, J. Cohen, S. Broder, S. H. Wilson   +4 more
semanticscholar   +1 more source

Rationally designed dual inhibitors of HIV reverse transcriptase and integrase.

Journal of Medicinal Chemistry, 2007
Bifunctional inhibitors were designed and synthesized based on 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)a1 non-nucleoside reverse transcriptase (RT) inhibitors and diketoacid (DKA) integrase (IN) inhibitors.
Zhengqiang Wang, E. Bennett, Daniel J. Wilson, C. Salomon, R. Vince   +4 more
semanticscholar   +1 more source

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine.

Antiviral Research, 2010
T. Cihlář, A. Ray
semanticscholar   +1 more source

Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ

, 1995
J. Cherrington, S. Allen, N. Bischofberger, M. S. Chen   +3 more
semanticscholar   +1 more source