Results 291 to 300 of about 12,878,485 (338)
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Retinoblastoma: Expression of HLA-G
Ocular Immunology and Inflammation, 2006Human leukocyte antigen (HLA) mediates interactions of tumor cells with cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Retinoblastoma (RB) is the most common intraocular malignant tumor in childhood and is characterized by direct spread to the optic nerve and orbit as well as hematogenous and lymphatic spread.
Mohan, Adithi +5 more
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Immunotolerant functions of HLA-G
Cellular and Molecular Life Sciences (CMLS), 1999HLA-G is a nonclassical major histocompatibility complex class I molecule selectively expressed on cytotrophoblasts at the fetal-maternal interface, where it plays a role in materno-fetal tolerance. In contrast to classical HLA-A, -B and -C class I molecules, HLA-G is characterized by (i) a tissue-restricted distribution, (ii) a limited polymorphism ...
E D, Carosella +2 more
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HLA‐G polymorphism and evolution
Tissue Antigens, 2007AbstractSix proteins, one null allele and 22 human leukocyte antigen (HLA)‐G alleles were found in humans. Bonobo, chimpanzee and gorilla only show one allele and orangutan shows five alleles. All Cercopithecus alleles show stop codons at position 164 (Macaca mulatta with seven DNA alleles, Macaca fascicularis with seven DNA alleles and Cercopithecus ...
A, Arnaiz-Villena +4 more
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HLA-G and Inflammatory Diseases
Inflammation & Allergy-Drug Targets, 2008HLA-G antigens are non classical HLA-class I molecules characterized by a low allelic polymorphism, a limited tissue distribution and the presence of membrane bound and soluble isoforms. The HLA-G antigens were firstly detected in cytotrophoblast cells at the feto-maternal interface where they maintain a tolerogenic status between the mother and the ...
BARICORDI, Olavio +3 more
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Human Immunology, 2015
Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue distribution expressed on the extra-villous trophoblast and seems to have immunomodulatory functions during pregnancy. Studies have linked HLA-G polymorphisms to pregnancy complications such as preeclampsia and recurrent miscarriage.
Dahl, Mette +8 more
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Human leukocyte antigen (HLA)-G is a class Ib molecule with restricted tissue distribution expressed on the extra-villous trophoblast and seems to have immunomodulatory functions during pregnancy. Studies have linked HLA-G polymorphisms to pregnancy complications such as preeclampsia and recurrent miscarriage.
Dahl, Mette +8 more
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Impaired spontaneous endocytosis of HLA‐G
European Journal of Immunology, 1997AbstractHLA‐G is a class Ib (non‐classical) major histocompatibility complex (MHC) protein expressed at the maternal‐fetal interface that inhibits natural killer (NK) cell‐mediated lysis in an allotype‐independent manner. Here we report that the spontaneous endocytosis of HLA‐G is severely reduced because of its short cytoplasmic tail.
Davis, Daniel M. +5 more
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Soluble HLA-G in Rheumatoid Arthritis
Human Immunology, 2006We investigated potential correlations between soluble HLA-G (sHLA-G) and soluble HLA class I (sHLA-I) levels, respectively, and parameters of disease activity or genetic factors determined by HLA-DRB1 and HLA-DQB1 in patients with rheumatoid arthritis (RA). SHLA-G plasma concentrations from 106 RA patients (mean age 59.8 years, 80 women) were assessed
Verbruggen, Leon +4 more
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Immunogenetics, 2003
During pregnancy, the human extra-villous trophoblast in the contact zone between maternal and fetal tissue in the placenta does not express the classical MHC class I and II molecules. Instead, HLA-G and -C, and possibly HLA-E, are expressed. HLA-G may modulate the immunological relationship between mother and fetus in several ways.
Hviid, Thomas Vauvert F +3 more
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During pregnancy, the human extra-villous trophoblast in the contact zone between maternal and fetal tissue in the placenta does not express the classical MHC class I and II molecules. Instead, HLA-G and -C, and possibly HLA-E, are expressed. HLA-G may modulate the immunological relationship between mother and fetus in several ways.
Hviid, Thomas Vauvert F +3 more
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Comparative reactivity of different HLA‐G monoclonal antibodies to soluble HLA‐G molecules
Tissue Antigens, 2000Different HLA‐G monoclonal antibodies (mAbs) were first evaluated for their capability to identify soluble HLA‐G (sHLA‐G) in ELISA. Three of them, namely 87G, BFL.1 and MEM‐G/9, when used as coating mAbs together with W6/32 capture mAb, identified β2‐microglobulin (β2m)‐associated‐sHLA‐G but not soluble HLA‐B7 (sHLA‐B7) in cell culture supernatants ...
S, Fournel +11 more
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