Results 231 to 240 of about 589,195 (286)

Trends in Rheumatoid Arthritis Mortality Among Postmenopausal Women in the United States, 1999–2023

iMetaMed, EarlyView.
RA‐related mortality among U.S. postmenopausal women has markedly declined since 1999. Despite this overall progress, significant inequalities by race, region, and age highlight ongoing challenges in achieving equitable health outcomes. ABSTRACT Rheumatoid arthritis (RA) disproportionately affects postmenopausal women, who are at an increased risk of ...
Yuhui Zhao, Weilu Cui, Yayun Han, Jun Qiao, Minjing Chang   +4 more
wiley   +1 more source

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

Correction: The impact of ageing on the distribution of preformed anti-HLA and anti-MICA antibody specificities in recipients from eastern China prior to initial HSCT

Immunity & Ageing
Qinqin Pan, Xiao Ma, Yajie You, Yuejiao Yu, Su Fan, Xiaoyan Wang, Mengyuan Wang, Ming Gao, Guangming Gong, Kourong Miao, Jie Shen, Xiaoyu Zhou   +11 more
doaj   +1 more source

Could vector-derived cadherin mimicry contribute to pemphigus vulgaris? An immunogenetic and <i>in silico</i> study involving HLA-DRB104:02 and 14:01. [PDF]

Front Immunol
Toraman B, Kasap BK, Ermis H, Arica DA, Yayli S.   +4 more
europepmc   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Impaired graft survival in kidney transplants from expanded criteria donors with HLA-DR mismatch. [PDF]

Front Transplant
Scheuermann U, Rhode P, Lehmann C, Kowald J, Seiffer S, Haak F, Seehofer D, Rabe SM, Tautenhahn HM.   +8 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Identification of a type 1 diabetes-associated T cell receptor repertoire signature from the human peripheral blood. [PDF]

Sci Adv
Rawat P, Shapiro MR, Peters LD, Widrich M, Mayer-Blackwell K, Motwani K, Pavlović M, Al Hajj G, Posgai AL, Kanduri C, Isacchini G, Chernigovskaya M, Scheffer L, Motwani K, Balzano-Nogueira LO, Pettenger-Willey CM, Valkiers S, Jacobsen LM, Haller MJ, Schatz DA, Wasserfall CH, Emerson RO, Fiore-Gartland AJ, Atkinson MA, Klambauer G, Sandve GK, Greiff V, Brusko TM.   +27 more
europepmc   +1 more source

Chinese pan‐cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real‐world clinical sequencing cohort

Interdisciplinary Medicine, EarlyView.
We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li   +10 more
wiley   +1 more source

Human leukocyte antigen variants and clinical features of primary biliary cholangitis: Cumulative contributions. [PDF]

World J Clin Cases
Bouayad A.
europepmc   +1 more source