Results 231 to 240 of about 401,649 (316)

A modular verification and validation framework for hybrid-capture next-generation sequencing HLA typing in clinical histocompatibility laboratories. [PDF]

Front Genet
Scarpa A, Ferrarese D, Guidotti S, Scaglia V, Rossi A.   +4 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Spatial Profiling Reveals Immune Escape Pathways and Therapeutic Vulnerabilities in Prostate Cancer Bone Metastases. [PDF]

Cancer Res
Owen KL, Gearing LJ, Niranjan B, Jayawardana M, Chadwick TB, Newman HI, Weng S, Trigos AS, Devereux LM, Campbell BK, Pasam A, Corcoran NM, Taylor RA, Hovens CM, Hertzog PJ, Sandhu S, Haynes NM, Parker BS.   +17 more
europepmc   +1 more source

A Tripartite Model for EBV‐Driven Multiple Sclerosis: B Cell Survival, Altered Self‐Presentation, and HLA‐DR15‐Restricted T Cell Cross‐Reactivity

iNew Medicine, EarlyView.
ABSTRACT This commentary integrates findings from three recent Cell reports to establish a unified mechanistic model of multiple sclerosis (MS) driven by the interplay between Epstein‐Barr virus (EBV) and the HLA‐DR15 genotype. EBV promotes CNS autoimmunity through three distinct but intersecting mechanisms.
Fang Zhu, Arnaud John Kombe Kombe, Tengchuan Jin   +2 more
wiley   +1 more source

Preclinical Characterization of CLSP-1025, a First-in-Class, Mutation-Specific T-Cell Engager Targeting a Neoantigen Derived from a Common p53 Mutation. [PDF]

Clin Cancer Res
Maloney MF, Caushi JX, Cullen LA, Andrews AR, Ford AC, Gizzi AS, Souza C, Stokes KL, Dobrev VS, Krapfl K, Curtis Siok M, Orlando DA, Bingham J, Kingsbury GA.   +13 more
europepmc   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

HLA-dependent association between EBNA1 antibody levels and disability progression in multiple sclerosis. [PDF]

J Neurol Neurosurg Psychiatry
Hedström AK, Thomas O, Strid P, Hillert J, Kockum I, Waterboer T, Olsson T, Alfredsson L.   +7 more
europepmc   +1 more source