Results 221 to 230 of about 111,549 (295)

Rad51 at the Crossroads: Bridging DNA Repair, Tumorigenesis, and Immune Regulation

Med Research, EarlyView.
Therapeutic landscape of Rad51 in cancer treatment. Key elements include (1) DNA damage sources (PARPi, chemo/radiotherapy); (2) repair pathways (Rad51‐mediated HR); (3) intervention strategies (Rad51 inhibitors, CRISPR/Cas9); and (4) combination approaches (immunotherapy). The figure is created with BioRender.com.
Zhendong Qin, Mingjun Lu, Jingwei Guo, Chenyang Wang, Teng Ma   +4 more
wiley   +1 more source

Framework for analyzing MAE-derived immunopeptidomes from cell lines with shared HLA haplotypes. [PDF]

PLoS One
Chan QWT, Baker TC, Kuan CW, Song L, Yu H, Foster LJ.   +5 more
europepmc   +1 more source

Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial

Movement Disorders, EarlyView.
Abstract Background Neuroinflammation contributes to Parkinson's disease (PD) progression and motor dysfunction. Allogeneic human mesenchymal stem cells (allo‐hMSCs) may reduce neuroinflammation and improve motor symptoms. Objectives To evaluate the efficacy of repeated intravenous doses of 10 × 106/kg allo‐hMSCs in improving motor symptoms in patients
Mya C. Schiess, Jessika Suescun, Juan D. Martinez‐Lemus, Charles Green, Tia S. Thomas, Mohammad Shahnawaz, Emily Tharp, Nikunj B. Satani, Jerome G. Saltarrelli, Christopher Adams, Marie‐Francoise Doursout, Vanessa Thyne, Rula Abuamouneh, Elsa M. Rodarte, Sean I. Savitz, Timothy M. Ellmore   +15 more
wiley   +1 more source

ImmuniT Platform for Improved Neoantigen Prediction in Lung Cancer. [PDF]

Vaccines (Basel)
Hachey SJ, Forsythe AG, Keshava HB, Hughes CCW.   +3 more
europepmc   +1 more source

Microbial Transglutaminase Increases Uptake and Translocation of Gliadin Peptides in the Human Intestinal Epithelium

Molecular Nutrition &Food Research, EarlyView.
The bacterial enzyme microbial transglutaminase (mTG) is widely used in the food industry as a technological aid to improve textural properties of a multitude of food products. mTG mimics the enzymatic function of human transglutaminase 2 (TG2) and may play a role in the pathogenesis of celiac disease.
Sebastian Stricker, Jan De Laffolie, Klaus‐Peter Zimmer, Silvia Rudloff   +3 more
wiley   +1 more source

An SNP-dependent cancer-testis antigenic epitope serves as a promising immunotherapeutic target for cancer. [PDF]

Oncoimmunology
Murata K, Minowa T, Tsukahara T, Yoshida T, Minami A, Nakatsugawa M, Mizue Y, Murai A, Tokita S, Sasaki K, Uhara H, Kubo T, Kanaseki T, Torigoe T, Hirohashi Y.   +14 more
europepmc   +1 more source

High‐Fat Diet–Wheat Gluten Interactions in HLA‐DQ8 Transgenic Mice

Molecular Nutrition &Food Research, EarlyView.
This study shows how eating a high‐fat diet (HFD) and gluten together influences inflammation, energy balance, and immune responses in HLA‐DQ8 transgenic (DQ8 tg) mice. These findings may provide new insights into how specific dietary components interact to impact metabolic and immune‐related disorders.
Yuri Haneishi, Lucia Treppiccione, Vera Rotondi Aufiero, Francesco Maurano, Saya Watanabe, Diomira Luongo, Giuseppe Mazzarella, Junki Miyamoto, Mauro Rossi   +8 more
wiley   +1 more source

Methodological approach for allele-specific antibody responses to HEK-293T-based cell lines expressing single MHC class I chain-related gene B antigens. [PDF]

BMC Mol Cell Biol
Jeon JH, Hong CH, Hyun YS, Lee H, Oh EJ, Kim TG, Baek IC.   +6 more
europepmc   +1 more source

Bifidobacteria and Celiac Disease: Mechanisms of Probiotic Action in Reducing Gluten‐Induced Cytotoxicity and Inflammation

Molecular Nutrition &Food Research, EarlyView.
Celiac disease (CD) is triggered by gluten in genetically predisposed individuals and is mainly treated with a gluten‐free diet. However, symptoms may persist. This review explores how certain Bifidobacterium strains may reduce inflammation and gluten toxicity through six mechanisms, including modulation of immune responses and gut microbiota.
Taynara Cipriano Scherer, Ivan De Marco, Natália Regina Coldebella Ferreira, Tatiana Colombo Pimentel, Marciane Magnani, Guilherme de Souza Hassemer, Amanda Bagolin do Nascimento, Silvani Verruck   +7 more
wiley   +1 more source