Results 171 to 180 of about 324,876 (288)

Rigid Boron‐Fused Frameworks for Efficient Near‐Infrared Emission and Optical Gain Beyond 900 nm

open access: yesAdvanced Optical Materials, EarlyView.
Multiple‐resonance (MR)‐derived boron‐fused frameworks were integrated into narrow‐gap, long‐range charge‐transfer emitters to reduce structural relaxation and electron‐vibrational coupling. This strategy significantly decreases nonradiative losses, leading to improved near‐infrared (NIR) luminescence efficiency and low‐threshold amplified spontaneous ...
Masashi Mamada   +6 more
wiley   +1 more source

Outcomes of germ line testing for children with hematologic malignancies undergoing hematopoietic cell transplantation. [PDF]

open access: yesBlood Adv
Pandey AS   +19 more
europepmc   +1 more source

Distributed Micropneumatic Sensors for Soft Robots to Detect Touch and Pose

open access: yesAdvanced Robotics Research, EarlyView.
Soft robots need integrated touch and pose sensing for safe and reliable operation. This work presents a three‐fingered soft gripper with 18 micropneumatic sensors made from the same materials as its pneumatic actuators. By measuring airflow resistance changes in deforming microchannels of the sensors, finger pose and contact are detected, enabling ...
Vilma Lampinen   +3 more
wiley   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

open access: yesAdvanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong   +7 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

open access: yesAdvanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu   +13 more
wiley   +1 more source

NADPH-depletion micelles sensitizing apoptotic and ferroptotic cancer therapy under hypoxia. [PDF]

open access: yesMater Today Bio
Lei T   +7 more
europepmc   +1 more source

An Adipocyte MKK3–p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity

open access: yesAdvanced Science, EarlyView.
The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo   +20 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

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