Results 221 to 230 of about 3,123,098 (233)

Structural Basis of Lymphangiogenic Receptor VEGFR‐3 Activation Mediated by Distinctive Clustering of the Ligand–Receptor Complex

Advanced Science, EarlyView.
VEGF‐C and its receptor VEGFR‐3 are critical for lymphangiogenesis. Cryo‐EM structures of the VEGFR‐3/VEGF‐C ectodomain complex reveal a canonical 2:2 ligand–receptor hetero‐tetramer that further assembles into higher‐order clusters beyond simple receptor dimerization.
Ryeongeun Cho, Jinsook Ahn, Jimin Yang, Dong Sun Lee, Gahi Hong, Sangkyu Lee, Ho Min Kim   +6 more
wiley   +1 more source

Gait and plantar pressure changes after medial open-wedge high tibial osteotomy combined with arthroscopic partial meniscectomy. [PDF]

Front Bioeng Biotechnol
Lu J, Peng Z, Gu Q, Wu X, Zhu Z, Liu G, Xu H, Tong L.   +7 more
europepmc   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Integration of the D‐Genome Reshapes Gene Transcription, Chromatin Architecture, and Metabolome of Allohexaploid Wheat, Leading to Enhanced Environmental Adaptability

Advanced Science, EarlyView.
Integration of the D‐genome reshapes gene transcription, chromatin architecture, and the metabolome of hexaploid wheat, leading to enhanced adaptability to salt, UV‐B, and alkali stress. ABSTRACT The hybridization‐led integration of the D‐genome into domesticated tetraploid wheat gave rise to allohexaploid wheat, the most cultivated wheat globally ...
Yanyan Liu, Tao Zhu, Ziru Zhou, Wei Chen, Chao He, Xinkai Zhou, Xin Wang, Chuanye Chen, Bo Yang, Jiaqi Wei, Caixia Lan, Mengmeng Liu, Handong Su, Qiang Li, Xin Hu, Siteng Bi, Weizhi Ouyang, Xingwang Li, Hailiang Mao, Masahiro Kishi, Kerstin Kaufmann, Alisdair R. Fernie, Dijun Chen, Wenhao Yan   +23 more
wiley   +1 more source

Comparison of Toxicity of Heavy Metals and Rare Earth Elements in Zebrafish Larvae and <i>Daphnia magna</i> Neonates Using a Phenomics Approach with Multiple Locomotor Activity Endpoints. [PDF]

Toxics
Khan BA, Tran MQ, Khan MB, Hsiao CD.
europepmc   +1 more source

Cytotoxic Effect of <i>Halimeda macroloba</i> Crude Extract on Cervical Cancer Spheroid Cells via p-mTOR/mTOR, Apoptosis, and Ferroptosis Pathways. [PDF]

Cancer Manag Res
Nittayaboon K, Leetanaporn K, Kerdkumthong K, Mayakun J, Navakanitworakul R.   +4 more
europepmc   +1 more source

Reheating-Induced Matrix Reorganisation Modulates the In Vitro Digestibility of a Retrograded Normal/High-Amylose Maize Starch Blend. [PDF]

Foods
Shao Z, Li C, Gao X, Li D, Lv H, Wang S.
europepmc   +1 more source

Harmine suppresses the malignant phenotypes of Lewis lung carcinoma cells by inhibiting EGFR phosphorylation. [PDF]

Am J Transl Res
Zhang X, Wang T, Hu Y, Fu C, Lian X, Li Y, Zhao R.   +6 more
europepmc   +1 more source

Manganese Transport and Sediment Remobilization in a Tidal Estuary: Parameter Sensitivity and Uncertainty Analysis. [PDF]

Toxics
Liu HM, Liu WC, Huang WC, Young CC.
europepmc   +1 more source