Results 41 to 50 of about 3,123,098 (233)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Performance based evaluation of chloride penetration resistance of high performance mortar with hollow microspheres developed for floating marine structures

Case Studies in Construction Materials
Due to the lack of land space from increasing population, number of marine structure construction has increased recently. In order to construct sustainable marine structures, the durability performance of concrete used for the construction in marine ...
Jin-Su Kim, Jae-Bin Jo, Jang-Ho Jay Kim
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Harmine ameliorates steroid-induced osteonecrosis of the femoral head by modulating metabolism and ferroptosis via HIF1-α

Fundamental Research
Steroid-induced osteonecrosis of the femoral head (SONFH) often leads to disability in the terminal stage, and there are still no effective drugs for prevention.
Wenming Li, Wei Zhang, Houyi Sun, Wenhao Li, Yi Qin, Liangliang Wang, Jiaxiang Bai, Dechun Geng   +7 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

HM&Co Lab

, 2017
Presentation of the research, innovation and outreach activities of the Hydrology Meteorology and Complexity Lab at École des Ponts ParisTech.Video: Rosa Vicari / HM&Co - École des Ponts ParisTechImages: Abdellah Ichiba, Auguste Gires, BlueGreenDream, HM&
Vicari, Rosa
core   +1 more source

Impact of Milk Fat Globule Membrane Phospholipids Addition on the in Vitro Digestion Characteristics of Infant Formula Emulsions

Shipin gongye ke-ji
Milk fat globule membrane (MFGM) is a key bioactive component in milk, incorporated into infant formula due to its health benefits. Previous studies have found that adding MFGM phospholipids to whey protein at an optimal ratio (MFGM phospholipids:whey ...
Ziyi ZHANG, Yanjie ZHAO, Lu LIU, He LI, Xiuxiu ZHANG, Xiaodong LI   +5 more
doaj   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Ratio Shared Task 2019

, 2019
<p>Ratio Shared Task 2019:</p> <p>Task 1 (same side classification)</p> <p> </p> <p>Task 2 (stance classification)</p ...
RATIO
core   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source