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A retrospective analysis of upfront treatment strategies in chronic myelomonocytic leukemia: impact on survival and response patterns. [PDF]

open access: yesHaematologica
Yousuf M   +14 more
europepmc   +1 more source
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Outcomes in AML patients receiving HMA + venetoclax combination with prior HMA exposure.

Journal of Clinical Oncology, 2021
e19011 Background: Venetoclax (Ven) is a BCL-2 inhibitor approved in combination with hypomethylating agents (HMAs) in newly diagnosed AML patients who are not candidates for intensive induction based on impressive response rates (CR+CRi of 66.4%) and median overall survival (14.7 months) compared to HMA therapy alone (DiNardo CD, NEJM, 2020).
Bakos Keegan Jonathan   +8 more
openaire   +1 more source

Novel therapies upon failure of HMA plus venetoclax

Hematology, 2023
Abstract The efficacy and tolerability of the combination of hypomethylating agents with venetoclax (HMA-VEN) in patients with newly diagnosed acute myeloid leukemia has been a practice-changing milestone in the field. However, treatment failure and relapse remain major barriers to prolonged survival.
Onyee, Chan, Alison R, Walker
openaire   +2 more sources

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